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Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
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Altered brain network integrity in patients with asthma: A structural connectomic diffusion tensor imaging study.

Xin Gao1, Yuan Xiao2, Peilin Lv3

  • 1Department of Radiology, West China Hospital, Sichuan University, Chengdu, China; Department of Radiology, People's Hospital of Deyang City, Deyang, China.

Respiratory Physiology & Neurobiology
|May 16, 2019
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Asthma patients show altered brain structural networks, with less efficient integration, particularly in frontal-limbic regions. These brain changes may contribute to asthma

Keywords:
AsthmaBrainConnectomeDepressionDiffusion tensor imaging

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Area of Science:

  • Neuroscience
  • Pulmonology
  • Medical Imaging

Background:

  • Asthma patients exhibit reported brain functional deficits.
  • These deficits are linked to treatment resistance and self-management issues.
  • Structural brain network changes in asthma remain unclear.

Purpose of the Study:

  • To investigate structural brain network differences in asthma patients.
  • To correlate these network changes with clinical and psychological assessments.

Main Methods:

  • Diffusion tensor imaging (DTI) was used to acquire brain data.
  • Structural network metrics were calculated for 54 asthma patients and 44 controls.
  • Hamilton Rating Scale for Depression and Anxiety and lung function tests were performed.

Main Results:

  • Asthma patients displayed higher path length and lower global efficiency, indicating more regular networks.
  • Abnormal nodal connectivity was observed in frontal-limbic regions.
  • Findings suggest less efficient integration of structural brain networks in asthma.

Conclusions:

  • Asthma is associated with altered structural brain networks, characterized by local segregation and reduced global integration.
  • Frontal-limbic network alterations are prominent in asthma patients.
  • These neurobiological changes may play a role in asthma pathophysiology.