Parenteral nutrition-associated cholestasis: recovery following phenobarbitone

A case is presented of a very preterm neonate who developed severe cholestatic jaundice in association with prolonged parenteral nutrition. The effects of a therapeutic trial of phenobarbitone on bilirubin and liver enzymes are shown. This case suggests that phenobarbitone may have a role to play in the treatment of this condition, which is contrary to indications in a few other case reports in the literature.