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Emerging erm(B)-Mediated Macrolide Resistance Associated with Novel Multidrug Resistance Genomic Islands in

Dejun Liu1,2, Weiwen Liu1,3, Ziquan Lv3

  • 1Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China.

Antimicrobial Agents and Chemotherapy
|May 16, 2019
PubMed

Insights

The macrolide resistance gene erm(B) is spreading rapidly in Campylobacter, often linked to multidrug resistance genomic islands. This increases antimicrobial resistance, limiting treatment options for campylobacteriosis.

Area of Science:

  • Veterinary Microbiology
  • Antimicrobial Resistance
  • Genomics

Background:

  • Macrolide resistance gene erm(B) is a growing concern for treating campylobacteriosis.
  • This gene is frequently associated with multidrug resistance genomic islands (MDRGIs), conferring resistance to multiple antimicrobials.
  • Understanding the spread and genetic context of erm(B) in Campylobacter is vital.

Purpose of the Study:

  • To investigate the prevalence and genetic environment of the erm(B) gene in Campylobacter isolates from food-producing animals in China.
  • To analyze the dissemination mechanisms and identify novel MDRGIs associated with erm(B).

Main Methods:

  • Collected 1,039 fecal samples from pigs and chickens across three regions in China.
  • Screened 290 Campylobacter isolates (C. coli and C. jejuni) for the erm(B) gene using PCR.
  • Performed pulsed-field gel electrophoresis (PFGE) to analyze genetic relatedness and dissemination.
  • Identified novel MDRGIs and characterized resistance mechanisms in C. jejuni isolates.

Main Results:

  • 74 out of 290 Campylobacter isolates (25.5%) were positive for erm(B), predominantly in C. coli (72/216).
  • A trend of increasing erm(B) prevalence in C. coli was observed over time.
  • PFGE indicated both clonal expansion and horizontal gene transfer contributed to erm(B) dissemination.
  • Three novel erm(B)-associated MDRGIs were identified.
  • Two C. jejuni isolates harbored erm(B) along with an aminoglycoside resistance island and RE-cmeABC efflux pump.
  • Most isolates exhibited resistance to multiple clinically important antimicrobials.

Conclusions:

  • The increasing prevalence of erm(B) and associated MDRGIs in Campylobacter poses a significant threat to public health.
  • These findings highlight the urgent need for continuous monitoring and control strategies to combat antimicrobial resistance in foodborne pathogens.
  • Treatment options for campylobacteriosis may be further compromised by the spread of these resistance genes.
Keywords:
CampylobacterMDRGIserm(B)macrolide resistance

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