Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics: Drug–Drug Interactions01:25

Pharmacokinetics: Drug–Drug Interactions

399
Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...
399
Cancer02:18

Cancer

53.8K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
53.8K
Bioequivalence of Drugs: Drugs with Multiple Indications01:09

Bioequivalence of Drugs: Drugs with Multiple Indications

155
The concept of therapeutic equivalence (TE) in drugs with multiple indications is complex. A generic drug may be therapeutically equivalent to a brand-name product for one specific indication, but this doesn't necessarily mean it's equivalent for all other indications. Evidence of TE in one patient group and bioequivalence shown in healthy volunteers can support—but not confirm—TE for other indications. However, definitive proof requires individual clinical studies for each...
155
FDA Approved Drugs: Changes to Approved Drugs01:26

FDA Approved Drugs: Changes to Approved Drugs

248
Post-approval, manufacturers may modify an approved new or generic drug product. Such modifications can encompass alterations in the Active Pharmaceutical Ingredient (API), manufacturing process, formulation, batch size, manufacturing site, and container closure system (FDA Guidance for Industry, April 2004). Often, a drug product may undergo multiple changes.These modifications require careful evaluation to determine their potential impact on the drug product's identity, strength, quality,...
248
What is Cancer?02:12

What is Cancer?

14.1K
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
14.1K
Factors Influencing Drug Absorption: Drug Dissolution01:27

Factors Influencing Drug Absorption: Drug Dissolution

1.1K
The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intraspecific divergence within <i>Microcystis aeruginosa</i> mediates the dynamics of freshwater harmful algal blooms under climate warming scenarios.

Proceedings. Biological sciences·2025
Same author

Standards for fecal microbiota transplant: Tools and therapeutic advances.

Biologicals : journal of the International Association of Biological Standardization·2024
Same author

Selection for oligotrophy among bacteria inhabiting host microbiomes.

mBio·2023
Same author

Authors' Response.

Journal of the Academy of Nutrition and Dietetics·2023
Same author

Gas Pressure From the Endoscope: An Unexplored Contributor to Morbidity and Mortality?

Cureus·2022
Same author

Nutrition and Microbiome Interactions in Human Cancer.

Journal of the Academy of Nutrition and Dietetics·2022

Related Experiment Video

Updated: Jan 25, 2026

Harvesting Venom Toxins from Assassin Bugs and Other Heteropteran Insects
09:45

Harvesting Venom Toxins from Assassin Bugs and Other Heteropteran Insects

Published on: April 21, 2018

13.9K

Bugs as Cancer Drugs: Challenges and Opportunities.

Phillip J Daschner1, Avraham Rasooly2, Jeffrey D White3

  • 1National Cancer Institute Division of Cancer Biology, Rockville, Maryland, USA.

Molecular and Cellular Biology
|May 16, 2019
PubMed
Summary

Bacterial therapy, an early cancer treatment, was abandoned due to ineffectiveness and harm. Renewed interest and National Cancer Institute funding are driving research into new bacterium-based cancer therapies for challenging conditions.

Keywords:
cancermicrobialtherapy

More Related Videos

A Method for Evaluating Insecticide Efficacy against Bed Bug, Cimex lectularius, Eggs and First Instars
06:04

A Method for Evaluating Insecticide Efficacy against Bed Bug, Cimex lectularius, Eggs and First Instars

Published on: March 15, 2017

11.8K
Using Single Sensillum Recording to Detect Olfactory Neuron Responses of Bed Bugs to Semiochemicals
06:55

Using Single Sensillum Recording to Detect Olfactory Neuron Responses of Bed Bugs to Semiochemicals

Published on: January 18, 2016

10.3K

Related Experiment Videos

Last Updated: Jan 25, 2026

Harvesting Venom Toxins from Assassin Bugs and Other Heteropteran Insects
09:45

Harvesting Venom Toxins from Assassin Bugs and Other Heteropteran Insects

Published on: April 21, 2018

13.9K
A Method for Evaluating Insecticide Efficacy against Bed Bug, Cimex lectularius, Eggs and First Instars
06:04

A Method for Evaluating Insecticide Efficacy against Bed Bug, Cimex lectularius, Eggs and First Instars

Published on: March 15, 2017

11.8K
Using Single Sensillum Recording to Detect Olfactory Neuron Responses of Bed Bugs to Semiochemicals
06:55

Using Single Sensillum Recording to Detect Olfactory Neuron Responses of Bed Bugs to Semiochemicals

Published on: January 18, 2016

10.3K

Area of Science:

  • Oncology
  • Microbiology
  • Medical History

Background:

  • Bacterial therapy was the first nonsurgical cancer treatment, introduced in 1891 for solid tumors.
  • It was discontinued due to significant harm and ineffectiveness, overshadowed by radiotherapy and chemotherapy.
  • Recent advancements in microbial therapies have revitalized interest in this approach.

Purpose of the Study:

  • To address the need for improved targeting of solid tumors.
  • To stimulate research into novel bacterium-based cancer therapies.
  • To explore therapeutic options for conditions where current cancer treatments are insufficient.

Main Methods:

  • Historical review of early bacterial therapy.
  • Analysis of recent progress in microbial therapy development.
  • Examination of National Cancer Institute funding initiatives.

Main Results:

  • Bacterial therapy, though historically significant, faced limitations.
  • Current research is exploring advanced microbial strategies for cancer treatment.
  • The National Cancer Institute is actively supporting new research in this field.

Conclusions:

  • Bacterium-based cancer therapy holds potential for treating solid tumors.
  • Further research is crucial to overcome historical limitations and develop effective microbial treatments.
  • This approach may offer new avenues for patients with inadequate treatment options.