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Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
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Expression of Sigma-Class Glutathione-S-Transferase in Fetal and Pediatric Filum Terminale Samples: A Comparative

Cahit Kural1, Serpil Oguztuzun2, Gülçin Güler Şimşek3

  • 1Department of Neurosurgery, University of Health Sciences, Gulhane Education and Research Hospital, 06010 Ankara, Turkey. cahitkural23@gmail.com.

Medicina (Kaunas, Lithuania)
|May 16, 2019
PubMed

Insights

Glutathione-S-transferase (GST) expression in the filum terminale (FT) may be linked to tethered cord syndrome (TCS) in children. Further research is needed to confirm the relationship between GST and TCS development.

Area of Science:

  • Pediatric Neurology
  • Developmental Biology
  • Biochemistry

Background:

  • The exact causes of tethered cord syndrome (TCS) in children remain unclear.
  • An inelastic filum terminale (FT) is a primary factor in spinal cord stretching associated with TCS.
  • Investigating enzyme expression in the FT may elucidate TCS pathophysiology.

Purpose of the Study:

  • To examine glutathione-S-transferase (GST) expression in fetal and pediatric filum terminale (FT) samples.
  • To explore the potential association between GST expression and the development of tethered cord syndrome (TCS).

Main Methods:

  • Histological and immunohistochemical analyses were performed on FT samples from children with TCS and normal fetuses.
  • Glutathione-S-transferase (GST) expression was evaluated in both groups.
  • Statistical comparison was conducted using a Chi-square test.

Main Results:

  • Positive GST-sigma expression was observed in 80% of pediatric TCS samples and 60% of fetal samples.
  • No statistically significant difference in GST-sigma expression was found between the pediatric TCS group and the fetal group (p = 0.197).

Conclusions:

  • Reduced filum terminale (FT) elasticity in tethered cord syndrome (TCS) might correlate with elevated GST expression.
  • Further prospective studies are essential to fully understand the GST-TCS relationship in pediatric patients.

Keywords:
childglutathione-S-transferasesurgerytethered cord syndrome

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