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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
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A Review on Daphnane-Type Diterpenoids and Their Bioactive Studies
Yue-Xian Jin1,2, Lei-Ling Shi3, Da-Peng Zhang4
1College of Chinese Medicine Material, Jilin Agricultural University, Changchun 130118, China. jyx0107@126.com.
Molecules (Basel, Switzerland)
|May 16, 2019
Summary
Daphnane diterpenoids from Thymelaeaceae and Euphorbiaceae plants exhibit diverse structures and potent biological activities. Research highlights their anti-cancer, anti-HIV, and cytotoxic effects, offering potential therapeutic applications.
Area of Science:
- Natural Products Chemistry
- Medicinal Chemistry
- Pharmacology
Background:
- Daphnane diterpenoids are natural compounds primarily found in Thymelaeaceae and Euphorbiaceae plants.
- These compounds feature a characteristic 5/7/6-tricyclic ring system with extensive hydroxylations and sometimes an orthoester motif.
- Nearly 200 daphnane-type diterpenoids have been identified and characterized.
Purpose of the Study:
- To review the structural diversity of daphnane-type diterpenoids.
- To summarize their biological activities, focusing on cytotoxic effects.
- To provide a comprehensive account up to April 2019.
Main Methods:
- Literature review of daphnane diterpenoids and their biological activities.
- Classification of daphnane diterpenoids based on structural features.
- Compilation of reported in-vitro and in-vivo experimental data.
Main Results:
- Daphnane diterpenoids are classified into five types based on structural characteristics.
- These compounds demonstrate a broad spectrum of biological activities, including anti-HIV, anti-cancer, anti-leukemic, neurotrophic, pesticidal, and cytotoxic effects.
- Significant structural variations exist within the daphnane diterpenoid class.
Conclusions:
- Daphnane diterpenoids represent a structurally diverse class of natural products with significant therapeutic potential.
- Their wide-ranging biological activities, particularly cytotoxicity, warrant further investigation for drug development.
- This review consolidates knowledge on daphnane diterpenoids, aiding future research efforts.
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