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Related Concept Videos

Polygenic Traits01:18

Polygenic Traits

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When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
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The term self-esteem is often used generically, to refer to how people feel about themselves. However, according to research, there are three distinct constructs that should not be used interchangeably (Brown & Marshall, 2006). 
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Traits and States01:17

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Personality traits represent consistent patterns in behavior, thoughts, and emotions, reflecting an individual's tendencies across various situations. For example, extraversion, a well-known trait, manifests in individuals as talkative, energetic, and enthusiastic behaviors. These traits are stable over time, offering a reliable framework for predicting how people might act in different contexts. However, they do not define every moment of an individual's life. In contrast to traits,...
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X-linked Traits01:19

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In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
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Trait Centrality01:21

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Trait centrality refers to the degree to which a particular characteristic influences the overall impression of an individual. Some traits exert a disproportionately strong impact on perception, shaping how people interpret other attributes of a person. Solomon Asch first systematically studied this phenomenon in 1946.Asch’s Experiment on Trait CentralityAsch's seminal study demonstrated the centrality of certain traits through a controlled experiment. Participants were presented with a...
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Related Experiment Video

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Single-cell Transcriptomic Analyses of Mouse Pancreatic Endocrine Cells
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Multi-tissue transcriptome analyses identify genetic mechanisms underlying neuropsychiatric traits.

Eric R Gamazon1,2,3,4,5, Aeilko H Zwinderman6, Nancy J Cox7,8

  • 1Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. egamazon@uchicago.edu.

Nature Genetics
|May 16, 2019
PubMed
Summary

Genetic predisposition to psychiatric disorders involves small-effect variants influencing gene expression. This study identifies trait-associated genes across brain, adrenal, and colon tissues, revealing non-brain tissues

Area of Science:

  • Psychiatric Genetics
  • Molecular Psychiatry
  • Systems Biology

Background:

  • Psychiatric disorders exhibit complex genetic architectures with numerous small-effect variants.

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  • These variants are often located in non-coding regions, implying a role in gene expression modulation.
  • Understanding the genetic basis requires examining diverse biological systems beyond the brain.