Related Experiment Video
Updated: Jan 25, 2026
In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Correlation between glycosylated hemoglobin level of patients with diabetes and cardiovascular disease
1Fengyun Wei, CPC Shandong Prov Comm, Party Sch. 250103, China.
Insights
Elevated glycosylated hemoglobin (HbA1c) in diabetic patients correlates with higher blood pressure and C-reactive protein. This suggests HbA1c can predict hypertension and coronary heart disease risk.
Area of Science:
- Endocrinology and Metabolism
- Cardiovascular Medicine
- Clinical Biochemistry
Background:
- Diabetes mellitus is a global health concern.
- Hypertension and coronary heart disease are common comorbidities in diabetic patients.
- Glycosylated hemoglobin (HbA1c) reflects long-term glycemic control.
Purpose of the Study:
- To investigate the relationship between glycosylated hemoglobin (HbA1c) levels and the prevalence of hypertension and coronary heart disease in diabetic patients.
- To explore the clinical significance of HbA1c in predicting these cardiovascular complications.
Main Methods:
- A cohort of 196 patients was studied, including 100 diabetic patients and 96 non-diabetic controls.
- Biochemical markers, including HbA1c, were compared between groups.
- Diabetic patients were subgrouped based on the presence of hypertension and coronary heart disease to analyze HbA1c levels.
Main Results:
- Diabetic patients exhibited significantly higher HbA1c, fasting plasma glucose, and high-sensitivity C-reactive protein (hs-CRP) compared to controls.
- HbA1c levels were significantly higher in diabetic patients with hypertension and coronary heart disease.
- HbA1c positively correlated with systolic blood pressure, diastolic blood pressure, and hs-CRP levels.
Conclusions:
- Glycosylated hemoglobin (HbA1c) levels in diabetic patients are positively associated with blood pressure and hs-CRP.
- HbA1c serves as an effective predictor for the development of hypertension and coronary heart disease.
- Monitoring HbA1c is crucial for screening diabetic patients at risk for hypertension and coronary heart disease.
Objective:
To explore the clinical influence of the changes of glycosylated hemoglobin level of patients with diabetes on hypertension and coronary heart disease.
Methods:
One hundred and ninety-six patients between February 2015 and December 2016 were divided into a control group (96 non-diabetic patients) and an observation group (100 patients with diabetes) with or without diabetes. The biochemical indexes of patients in the two groups were compared. Moreover patients in the observation groups were divided into subgroups according to the presence of hypertension and coronary heart disease, and the level of HbA1c was compared between different subgroups.
Results:
The levels of total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) of patients in the two groups had no significant differences (P>0.05). However, the level of high-density lipoprotein cholesterol (HDL-C) of patients in the observation group was significantly lower than that of the control group (P<0.05). The Systolic Blood Pressure (SBP) and diastolic blood pressure (DBP), fasting plasma glucose (FPG), fasting insulin (FINS) and levels of high-sensitivity C-reactive protein (hs-CRP) and HbA1c of patients in the observation group were apparently higher than those of the control group (P<0.05). The level of HbA1c of patients with hypertension was significantly higher than that without hypertension (P<0.05). The level of HbA1c of patients with coronary heart disease was apparently higher than that without coronary heart disease (P<0.05). The Pearson correlation analysis results demonstrated that the level of HbA1c of patients in the diabetes group was in a positive correlation with SBP, DBP and level of hs-CRP (P<0.05).
Conclusion:
The level of HbA1c of patients with diabetes was in a positive correlation with blood pressure and level of hs-CRP. The level of HbA1c can effectively predict the occurrence of hypertension and coronary heart disease. Detecting level of glycosylated hemoglobin is of important significance in screening patients with hypertension and coronary heart disease.
Related Concept Videos
01:27Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
01:24Hemoglobin
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
01:25Protein Glycosylation
Glycosylation occurs in...
02:20Correlations
01:27Correlation and Causation
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
01:09Correlation
Two variables, for example, a and b, are said to be positively correlated if both variables move in the same direction. In other words, a positive correlation exists between two variables, a and b, if: