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Evaluating diurnal changes in choroidal sublayer perfusion using optical coherence tomography angiography.

Fynn Siegfried1,2, Felix Rommel1,2, Matthias Rothe1,2

  • 1Department of Ophthalmology, University of Lübeck, Lübeck, Germany.

Acta Ophthalmologica
|May 16, 2019
PubMed
Summary

Choroidal sublayer perfusion shows significant diurnal variations, with thickness changing throughout the day. Mean arterial pressure and age influence these changes, highlighting the importance of considering time of day for OCTA data.

Keywords:
Haller's layerSattler's layerchoriocapillarischoroidal perfusiondiurnal variationoptical coherence tomography angiography

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Human Physiology

Background:

  • Choroidal perfusion is crucial for retinal health.
  • Understanding diurnal variations in choroidal structure is essential for accurate interpretation of imaging data.
  • Optical coherence tomography angiography (OCTA) allows for detailed visualization of choroidal vasculature.

Purpose of the Study:

  • To investigate diurnal changes in choroidal sublayer perfusion in healthy eyes.
  • To identify factors influencing these diurnal variations using OCTA.
  • To establish the clinical relevance of temporal changes in choroidal imaging.

Main Methods:

  • Prospective study involving healthy volunteers.
  • Repeated measurements of subfoveal choroidal thickness (SFCT) and choroidal vascular sublayer perfusion using enhanced depth imaging OCT and OCTA at multiple time points (7 a.m., 12 p.m., 4 p.m., 8 p.m.).
  • Statistical analysis to evaluate diurnal variations and correlations with mean arterial pressure (MAP), gender, and age.

Main Results:

  • Significant diurnal variations observed in SFCT, Sattler's layer perfusion (SLP), and Haller's layer perfusion (HLP).
  • SFCT showed a linear decrease from morning to evening.
  • HLP changes were associated with MAP fluctuations, and older participants exhibited fewer diurnal changes.

Conclusions:

  • OCTA reveals significant diurnal variations in choroidal sublayer perfusion.
  • Time of day is a critical factor to consider when comparing longitudinal OCTA data.
  • These findings have implications for the interpretation of choroidal imaging studies and clinical assessments.