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Future topical medications in chronic rhinosinusitis.
Michelle Menon Miyake1, Benjamin S Bleier1
1Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA.
International Forum of Allergy & Rhinology
|May 16, 2019
Summary
Topical medications offer promising potential for treating chronic rhinosinusitis (CRS), addressing challenges like biofilms and resistant bacteria. Further research is needed to optimize drug delivery and identify new local targets for effective sinonasal treatment.
Area of Science:
- Otolaryngology
- Pharmacology
- Infectious Diseases
Background:
- Chronic rhinosinusitis (CRS) management is evolving, with challenges in eradicating biofilms and multidrug-resistant bacteria.
- Oral antibiotics show limitations in effectively treating persistent CRS.
- Topical medication presents a potential alternative for CRS treatment.
Purpose of the Study:
- To review and discuss the potential of topical medications for chronic rhinosinusitis (CRS).
- To identify the challenges and limitations associated with topical CRS treatments.
- To explore future directions in topical CRS therapy.
Main Methods:
- A literature review was conducted using PubMed and Scopus databases.
- English-language publications were exclusively included.
- Selected therapies were categorized and analyzed.
Main Results:
- Topical treatments are being explored for chronic rhinosinusitis (CRS).
- The review summarizes current and future topical strategies for CRS.
- Challenges in drug delivery and target identification were discussed.
Conclusions:
- The sinonasal mucosa's accessibility favors topical CRS treatment.
- Further understanding of local targets and improved drug delivery methods are crucial.
- Successful adoption of topical agents requires continued research and development.
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