Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy01:16

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

1.2K
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
1.2K
Transcription Attenuation in Prokaryotes02:42

Transcription Attenuation in Prokaryotes

18.2K
Transcriptional attenuation occurs when RNA transcription is prematurely terminated due to the formation of a terminator mRNA hairpin structure.  Bacteria use these hairpins to regulate the transcription process and control the synthesis of several amino acids including histidine, lysine, threonine, and phenylalanine. Transcription attenuation takes place in the non-coding regions of mRNA.
There are several different mechanisms used to attenuate transcription. In ribosome mediated...
18.2K
Intrinsically Disordered Proteins02:18

Intrinsically Disordered Proteins

19.3K
Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
19.3K
Viral Recombination00:57

Viral Recombination

25.0K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
25.0K
CRISPR and crRNAs02:53

CRISPR and crRNAs

18.8K
Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
18.8K
Amyloid Fibrils03:03

Amyloid Fibrils

11.7K
Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
11.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Negligible Rebound in Myopia Progression Following Cessation of Treatment with 0.01% Atropine for 3 years: Year-4 Results from the CHAMP Phase 3 Clinical Trial.

Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)·2026
Same author

The Impact of Periprocedural Yoga Therapy on Patients Receiving Interventional Procedures for Chronic Pain.

Journal of integrative and complementary medicine·2026
Same author

Axial length as a function of age, sex, and ethnicity: Results from the CLEERE study.

Optometry and vision science : official publication of the American Academy of Optometry·2025
Same author

Hepatocellular Carcinoma Recurrence in Patients with Chronic Hepatitis C Infection Treated with Direct-Acting Antivirals: A Systematic Review and Meta-Analysis.

Infectious diseases and therapy·2025
Same author

Cornea Classic: Nichols, Nichols, and Mitchell, "The Lack of Association Between Signs and Symptoms in Patients With Dry Eye Disease" (2004).

Cornea·2025
Same author

Performance of molecular tests for diagnosis of bloodstream infections in the clinical setting: a systematic literature review and meta-analysis.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2024

Related Experiment Video

Updated: Jan 24, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

20.4K

Intrastromal corneal ring segments for treating keratoconus.

Karla Zadnik1, Sarah Money, Kristina Lindsley

  • 1College of Optometry, The Ohio State University, 338 West Tenth Avenue, Columbus, Ohio, USA, OH 43210.

The Cochrane Database of Systematic Reviews
|May 16, 2019
PubMed
Summary

No randomized controlled trials were found comparing intrastromal corneal ring segments to spectacles or contact lenses for keratoconus treatment. Therefore, no conclusions can be drawn regarding their effectiveness or safety.

More Related Videos

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures
04:48

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures

Published on: November 22, 2024

815
Author Spotlight: Decoding Corneal Neovascularization with Alkali Burn Model for Future Therapeutic Strategies
04:17

Author Spotlight: Decoding Corneal Neovascularization with Alkali Burn Model for Future Therapeutic Strategies

Published on: June 30, 2023

3.9K

Related Experiment Videos

Last Updated: Jan 24, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

20.4K
Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures
04:48

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures

Published on: November 22, 2024

815
Author Spotlight: Decoding Corneal Neovascularization with Alkali Burn Model for Future Therapeutic Strategies
04:17

Author Spotlight: Decoding Corneal Neovascularization with Alkali Burn Model for Future Therapeutic Strategies

Published on: June 30, 2023

3.9K

Area of Science:

  • Ophthalmology
  • Corneal Surgery
  • Vision Science

Background:

  • Keratoconus is a progressive corneal disease causing vision impairment.
  • Intrastromal corneal ring segments (ICRS) are PMMA devices used to flatten the cornea.
  • ICRS are indicated when glasses or contact lenses are insufficient for keratoconus management.

Purpose of the Study:

  • To assess the efficacy and safety of intrastromal corneal ring segments for keratoconus.
  • To identify and synthesize evidence from randomized controlled trials (RCTs).

Main Methods:

  • Comprehensive literature search of multiple databases including CENTRAL, MEDLINE, Embase, PubMed, LILACS, and clinical trial registries.
  • Independent screening of records and full-text articles by two review authors.
  • No date or language restrictions were applied to the search.

Main Results:

  • The systematic search identified no eligible randomized controlled trials comparing intrastromal corneal ring segments with spectacles or contact lenses.
  • The absence of RCTs prevents direct comparison of ICRS to standard corrective measures.

Conclusions:

  • Due to the lack of high-quality evidence from RCTs, the effectiveness and safety of intrastromal corneal ring segments for keratoconus cannot be determined.
  • Further research in the form of well-designed RCTs is needed to establish the role of ICRS in keratoconus management.