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Updated: Jan 24, 2026

Cerenkov Luminescence Imaging CLI for Cancer Therapy Monitoring
Published on: November 13, 2012
Monitorable Mitochondria-Targeting DNAtrain for Image-Guided Synergistic Cancer Therapy
Tao Jiang1,2, Lihua Zhou2, Haixiang Liu2,3
1Department of Pharmaceutical Sciences, Nanfang Hospital , Southern Medical University , 1838 North Guangzhou Avenue , Guangzhou , Guangdong 510515 , P. R. China.
Abstract:
It is highly desirable to realize real-time monitoring of the drug delivery/release process in cancer treatment. Herein, a monitorable mitochondria-specific DNAtrain (MitoDNAtrs) was developed for image-guided drug delivery and synergistic cancer therapy. In this system, mitochondria-targeting Cy5.5 dye served as the "locomotive" to guide the DNA "vehicle" selectively accumulating in the cancer cells in a detectable manner. More importantly, Cy5.5 showed reactive oxygen species (ROS) generation ability, which made it a promising adjuvant chemotherapy amplifier for cancer theranostics.
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