Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

1.3K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.3K
The Quantum-Mechanical Model of an Atom02:45

The Quantum-Mechanical Model of an Atom

56.8K
Shortly after de Broglie published his ideas that the electron in a hydrogen atom could be better thought of as being a circular standing wave instead of a particle moving in quantized circular orbits, Erwin Schrödinger extended de Broglie’s work by deriving what is now known as the Schrödinger equation. When Schrödinger applied his equation to hydrogen-like atoms, he was able to reproduce Bohr’s expression for the energy and, thus, the Rydberg formula governing hydrogen spectra.
56.8K
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

247
Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
247
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

971
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
971
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.2K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.2K
Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model01:13

Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model

303
Drugs administered through various routes can lead to nonlinear elimination, resulting in complex pharmacokinetic behaviors crucial to understanding efficacious drug dosing.
When a drug is administered through a constant intravenous infusion and eliminated via nonlinear pharmacokinetics, it follows zero-order input. For example, oral drugs undergo first-order absorption upon administration and are eliminated through nonlinear pharmacokinetics.
In the case of subcutaneously administered drugs,...
303

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microtopography screening to modulate the mitogenic effects of aqueous humor on human tenon fibroblasts.

Frontiers in bioengineering and biotechnology·2026
Same author

A coordinated transcriptional program controls de novo Golgi biogenesis.

The EMBO journal·2026
Same author

Response to correspondence: "Reappraising the neurovascular link between arterial stiffness and neuropathy: proposal for a neurovascular uncoupling index".

Journal of hypertension·2026
Same author

The Association Between Adherence to the Dutch Healthy Diet Index and Glaucoma Prevalence-The Maastricht Study.

Nutrients·2026
Same author

Association of tear fluid glutathione synthetase and glutathione levels with amyloid positivity.

Scientific reports·2026
Same author

The Floor-Ceiling-Chip, or 2 × 2D = Pseudo-3D-Approaching 3D Cell Morphology and Organization between Two Opposing 2D Substrates with Cell-Adhesive Protein Micropatterns.

Advanced healthcare materials·2026

Related Experiment Video

Updated: Jan 24, 2026

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice
07:00

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice

Published on: October 5, 2018

11.0K

Modeling the Mechanical Parameters of Glaucoma.

Pascal A M M Vroemen1,2,3, Theo G M F Gorgels1,4, Carroll A B Webers1

  • 1University Eye Clinic Maastricht UMC+, Maastricht University Medical Centre+, Maastricht, The Netherlands.

Tissue Engineering. Part B, Reviews
|May 16, 2019
PubMed
Summary
This summary is machine-generated.

Developing new glaucoma drugs requires better models. This review examines mechanical stress models for retinal ganglion cell death, highlighting the need for improved systems to screen potential vision-protecting therapies.

Keywords:
biomechanical modelsglaucomahydrostatic pressurestrain

More Related Videos

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.6K
Ultrasound Cyclo Plasty in Eyes with Glaucoma
05:05

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Published on: January 26, 2018

12.7K

Related Experiment Videos

Last Updated: Jan 24, 2026

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice
07:00

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice

Published on: October 5, 2018

11.0K
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.6K
Ultrasound Cyclo Plasty in Eyes with Glaucoma
05:05

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Published on: January 26, 2018

12.7K

Area of Science:

  • Ophthalmology and Vision Science
  • Biomedical Engineering
  • Cellular and Molecular Biology

Background:

  • Glaucoma causes progressive retinal ganglion cell (RGC) loss, driven by biomechanical forces like hydrostatic pressure and strain.
  • Current intraocular pressure-lowering therapies are insufficient to prevent blindness in many glaucoma patients.
  • There is a critical need for novel drugs and effective screening models to protect RGCs.

Purpose of the Study:

  • To review and assess existing mechanical model systems used to mimic glaucoma-induced biomechanical forces.
  • To investigate molecular and cellular events leading to mechanically induced RGC death.
  • To identify gaps and guide the development of improved glaucoma and drug screening models.

Main Methods:

  • Focus on *in vitro* and *ex vivo* models, as *in vivo* models are unsuitable for drug screening.
  • Analysis of models employing cell or tissue strain, or hydrostatic pressure (fluid/gas-controlled).
  • Examination of models applied to relevant cell types (trabecular meshwork cells, astrocytes, RGCs) and whole eyes.

Main Results:

  • Current mechanical models vary widely in their outcomes for investigating RGC death.
  • The development of a robust, standardized glaucoma model remains elusive.
  • A comprehensive overview of current mechanical model systems for glaucoma research is lacking.

Conclusions:

  • Existing mechanical models show significant variability, indicating the need for more robust systems.
  • New model systems are essential for studying glaucoma pathogenesis and testing therapeutic compounds.
  • This review consolidates current knowledge to facilitate the development of improved glaucoma research models.