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The Canadian childhood nephrotic syndrome (CHILDNEPH) study: report on mid-study feasibility, recruitment and main

Susan M Samuel1, Allison Dart2, Guido Filler3

  • 1Section of Nephrology, Departments of Pediatrics and Community Health Sciences, Alberta Children's Hospital Research Institute, O'Brien Institute for Public Health, University of Calgary, 2888 Shaganappi Trail NW, Calgary, Alberta, T3B 6A8, Canada. susan.samuel@ahs.ca.

BMC Nephrology
|May 16, 2019
PubMed

Insights

Practice variations persist in managing childhood nephrotic syndrome. This study tracks patient and physician data to understand and address these differences in treatment for better outcomes.

Area of Science:

  • Pediatric Nephrology
  • Clinical Practice Variation
  • Longitudinal Cohort Studies

Background:

  • Childhood nephrotic syndrome management guidelines exist.
  • Practice variations continue despite established guidelines.
  • Reasons for persistent practice variation require investigation.

Purpose of the Study:

  • Assess practice variation in childhood nephrotic syndrome management.
  • Describe patient and physician recruitment characteristics.
  • Analyze glucocorticoid prescriptions and second-line agent use.

Main Methods:

  • Longitudinal cohort study in Canadian pediatric nephrology centers.
  • Recruitment of children with new onset nephrotic syndrome and providers.
  • Data collection over minimum 36 months, including relapses and treatment details.

Main Results:

  • 243 patients enrolled from 12 centers.
  • Median 29 patients per center; median age 7.3 years.
  • Observed cumulative dose variability in glucocorticoids and treatment duration between centers.

Conclusions:

  • Canadian pediatric nephrology community confirms ongoing practice variability.
  • Study aims to evaluate the impact of variability on patient outcomes.
  • Facilitates clinical trial implementation for nephrotic syndrome.
Abstract

Keywords:
ChildrenGlucocorticoidsLongitudinal studyNephrotic syndromePractice variation

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