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Pediatric onset multiple sclerosis

K Deiva1

  • 1Service de neurologie pédiatrique, CRMR maladies inflammatoires rares du cerveau et de la moelle (MIRCEM), assistance publique-hôpitaux de Paris, hôpitaux universitaires Paris-Sud, Site Bicêtre, 72, rue G-Leclerc, 94275 Le Kremlin Bicêtre, France; Inserm UMR1184 « Immunology of viral infections and autoimmune diseases », CEA, IDMIT, faculté de médecine Paris Sud-XI, faculté de médecine Paris-Sud, 63, rue Gabriel-Peri 94276 Le Kremlin-Bicêtre, France.

Revue Neurologique
|May 16, 2019
PubMed

Insights

Pediatric onset multiple sclerosis (POMS) is rare but has unique characteristics. This review details the specific features of POMS in children, differentiating it from adult forms of the disease.

Area of Science:

  • Neurology
  • Immunology
  • Pediatrics

Background:

  • Multiple Sclerosis (MS) is a leading inflammatory demyelinating disease.
  • While common in adults, pediatric onset MS (POMS) is infrequent in children.
  • Distinct clinical and pathological features characterize POMS.

Purpose of the Study:

  • To comprehensively review the defining characteristics of pediatric onset multiple sclerosis (POMS).
  • To highlight the unique aspects of POMS in the pediatric population.
  • To provide an overview of POMS for clinicians and researchers.

Main Methods:

  • Literature review of studies focusing on pediatric onset multiple sclerosis.
  • Analysis of epidemiological data related to POMS.
  • Synthesis of clinical, radiological, and immunological findings in POMS.

Main Results:

  • POMS presents with specific epidemiological patterns.
  • Clinical manifestations and disease course in children differ from adults.
  • Diagnostic criteria and treatment considerations for POMS are being refined.

Conclusions:

  • Pediatric onset multiple sclerosis is a distinct entity within the spectrum of MS.
  • Understanding POMS' unique characteristics is crucial for accurate diagnosis and management.
  • Further research is needed to fully elucidate the long-term outcomes and optimal therapies for POMS.

Keywords:
Clinical NeuroscienceNeuroimmunologyPediatric Neurology

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