Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multiple Allele Traits01:49

Multiple Allele Traits

38.0K
The Concept of Multiple Allelism
38.0K
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

214
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
214
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

276
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
276
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

200
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
200
Multiple Regression01:25

Multiple Regression

3.8K
Multiple regression assesses a linear relationship between one response or dependent variable and two or more independent variables. It has many practical applications.
Farmers can use multiple regression to determine the crop yield based on more than one factor, such as water availability, fertilizer, soil properties, etc. Here, the crop yield is the response or dependent variable as it depends on the other independent variables. The analysis requires the construction of a scatter plot...
3.8K
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

261
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
261

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neurological manifestations in children with SARS-CoV-2 infection: a French multicentric cohort.

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society·2025
Same author

French guidelines for the diagnosis and management of MOG antibody-associated disease.

Revue neurologique·2025
Same author

Frequency and clinical relevance of MOG-antibodies in CSF in pediatric patients with MOG antibody-associated diseases.

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society·2024
Same author

Editorial on EJPN focus section on E.U. paediatric MOG consortium consensus statements.

European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society·2020
Same author

MRI characteristics of MOG-Ab associated disease in adults: An update.

Revue neurologique·2020
Same author

Treatment of MOG antibody associated disorders: results of an international survey.

Journal of neurology·2020

Related Experiment Video

Updated: Jan 24, 2026

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

58.7K

Pediatric onset multiple sclerosis.

K Deiva1

  • 1Service de neurologie pédiatrique, CRMR maladies inflammatoires rares du cerveau et de la moelle (MIRCEM), assistance publique-hôpitaux de Paris, hôpitaux universitaires Paris-Sud, Site Bicêtre, 72, rue G-Leclerc, 94275 Le Kremlin Bicêtre, France; Inserm UMR1184 « Immunology of viral infections and autoimmune diseases », CEA, IDMIT, faculté de médecine Paris Sud-XI, faculté de médecine Paris-Sud, 63, rue Gabriel-Peri 94276 Le Kremlin-Bicêtre, France.

Revue Neurologique
|May 16, 2019
PubMed
Summary
This summary is machine-generated.

Pediatric onset multiple sclerosis (POMS) is rare but has unique characteristics. This review details the specific features of POMS in children, differentiating it from adult forms of the disease.

Keywords:
Clinical NeuroscienceNeuroimmunologyPediatric Neurology

More Related Videos

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

12.0K
A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS
08:18

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS

Published on: December 26, 2015

18.1K

Related Experiment Videos

Last Updated: Jan 24, 2026

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

58.7K
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

12.0K
A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS
08:18

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS

Published on: December 26, 2015

18.1K

Area of Science:

  • Neurology
  • Immunology
  • Pediatrics

Background:

  • Multiple Sclerosis (MS) is a leading inflammatory demyelinating disease.
  • While common in adults, pediatric onset MS (POMS) is infrequent in children.
  • Distinct clinical and pathological features characterize POMS.

Purpose of the Study:

  • To comprehensively review the defining characteristics of pediatric onset multiple sclerosis (POMS).
  • To highlight the unique aspects of POMS in the pediatric population.
  • To provide an overview of POMS for clinicians and researchers.

Main Methods:

  • Literature review of studies focusing on pediatric onset multiple sclerosis.
  • Analysis of epidemiological data related to POMS.
  • Synthesis of clinical, radiological, and immunological findings in POMS.

Main Results:

  • POMS presents with specific epidemiological patterns.
  • Clinical manifestations and disease course in children differ from adults.
  • Diagnostic criteria and treatment considerations for POMS are being refined.

Conclusions:

  • Pediatric onset multiple sclerosis is a distinct entity within the spectrum of MS.
  • Understanding POMS' unique characteristics is crucial for accurate diagnosis and management.
  • Further research is needed to fully elucidate the long-term outcomes and optimal therapies for POMS.