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The Calcium-Signaling Toolkit in Cancer: Remodeling and Targeting

Sarah J Roberts-Thomson1, Silke B Chalmers1, Gregory R Monteith1,2

  • 1The School of Pharmacy, The University of Queensland, Brisbane, Queensland 4072, Australia.

Cold Spring Harbor Perspectives in Biology
|May 16, 2019
PubMed

Insights

Calcium (Ca2+) signaling pathways are crucial in cancer progression, influencing cell growth, invasion, and death resistance. Understanding the Ca2+ signaling toolkit

Area of Science:

  • Oncology
  • Cell Biology
  • Biochemistry

Background:

  • Cancer progression involves sustained cell growth, invasion, and resistance to cell death.
  • Calcium (Ca2+) signaling pathways regulate key cellular processes.
  • The Ca2+ signaling toolkit comprises proteins vital for cellular functions.

Purpose of the Study:

  • To review the role of Ca2+ signaling in tumor progression.
  • To highlight the interplay between the Ca2+ signaling toolkit and tumorigenesis.
  • To identify areas needing further research in cancer and Ca2+ signaling.

Main Methods:

  • Literature review of Ca2+ signaling in cancer.
  • Analysis of proteins involved in Ca2+ signaling pathways.
  • Examination of Ca2+ signaling's role in tumor microenvironment and therapy resistance.

Main Results:

  • Ca2+ signaling pathways overlap with critical cancer progression processes.
  • Ca2+ signaling proteins contribute to cancer cell proliferation, invasiveness, and death resistance.
  • Ca2+ signaling impacts tumor microenvironment and anticancer therapy resistance.

Conclusions:

  • Ca2+ signaling is integral to multiple facets of cancer progression.
  • Further investigation into the Ca2+ signaling toolkit's role in tumorigenesis is warranted.
  • Targeting Ca2+ signaling pathways may offer novel therapeutic strategies.

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