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Recurrent oral ulceration: Etiology, classification, management, and diagnostic algorithm.

Elizabeth A Bilodeau1, Rajesh V Lalla2

  • 1Department of Diagnostic Sciences, University of Pittsburgh School of Dental Medicine, Pittsburgh, Pennsylvania, USA.

Periodontology 2000
|May 16, 2019
PubMed
Summary

Recurrent oral ulcerations stem from diverse causes like infections, medications, and systemic diseases. This review details their causes, diagnosis, and management, offering a diagnostic guide.

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Area of Science:

  • Oral Medicine
  • Pathology
  • Immunology

Background:

  • Recurrent oral ulcerations present a complex clinical challenge.
  • Etiologies are diverse, ranging from local trauma to systemic conditions.
  • Accurate diagnosis is crucial for effective management.

Purpose of the Study:

  • To review the pathogenesis, clinical presentation, diagnosis, and management of common recurrent oral ulcerations.
  • To cover various etiologies including traumatic, chemical, infectious, medication-related, and autoimmune causes.
  • To present a diagnostic algorithm for recurrent oral ulceration.

Main Methods:

  • Literature review of scientific articles and clinical guidelines.
  • Synthesis of information on pathogenesis, clinical features, and diagnostic approaches.
  • Development of a structured diagnostic algorithm.

Main Results:

  • Common causes identified: traumatic, chemical, recurrent aphthous stomatitis, medication-related, infectious, mucocutaneous, and autoimmune/systemic diseases.
  • Detailed discussion of each etiology's characteristics.
  • A practical diagnostic algorithm is provided to aid clinicians.

Conclusions:

  • Recurrent oral ulcerations require a systematic diagnostic approach.
  • Understanding the diverse etiologies is key to appropriate patient care.
  • The presented algorithm facilitates differential diagnosis and management planning.