Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bile01:19

Bile

4.0K
Bile is a crucial bodily fluid, characterized by its yellow-green color and alkaline nature. Produced in the liver, it is transported through the common hepatic duct into either the cystic duct, leading to the gallbladder, or directly into the common bile duct. The flow of bile is regulated by the sphincter of Oddi located at the entrance of the duodenum. When this sphincter is closed, bile is redirected to the gallbladder for storage and concentration.
Bile is released when dietary fats enter...
4.0K
Accessory Organs01:31

Accessory Organs

74.0K
Accessory organs are those that participate in the digestion of food but do not come into direct contact with it like the mouth, stomach, or intestine do. Accessory organs secrete enzymes into the digestive tract to facilitate the breakdown of food.
74.0K
Lipid Digestion01:06

Lipid Digestion

99.0K
Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
99.0K
Hormonal Regulation01:40

Hormonal Regulation

47.9K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
47.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Minimizing and/or Avoiding Disease Progression Risk in Patients With the Three Highs: A Grounded Theory Study.

Qualitative health research·2025
Same author

The Various Mechanisms by Which Exercise-Induced Fatigue (EIF) Affects Spermatogenesis Through Testosterone.

Reproductive sciences (Thousand Oaks, Calif.)·2025
Same author

[Retracted] Arnebin‑1 promotes angiogenesis by inducing eNOS, VEGF and HIF‑1α expression through the PI3K‑dependent pathway.

International journal of molecular medicine·2023
Same author

Lactation breast abscess treated with Gualou Xiaoyong decoction and painless lactation manipulation: A case report and review of literature.

World journal of clinical cases·2023
Same author

Analysis of appendicitis management during COVID-19 pandemic: A study of Chinese adult cohorts.

Frontiers in surgery·2022
Same author

Self-protective responses to norvaline-induced stress in a leucyl-tRNA synthetase editing-deficient yeast strain.

Nucleic acids research·2017

Related Experiment Video

Updated: Jan 24, 2026

Laparoscopic Common Bile Duct Exploration Followed by Primary Suture Using a Modified Bile Duct Incision
05:36

Laparoscopic Common Bile Duct Exploration Followed by Primary Suture Using a Modified Bile Duct Incision

Published on: May 2, 2025

650

Bile-ology: from bench to bedside.

Li-Hua Jin1,2, Zhi-Peng Fang1, Min-Jie Fan3

  • 1Department of Diabetes Complications and Metabolism, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.

Journal of Zhejiang University. Science. B
|May 16, 2019
PubMed
Summary
This summary is machine-generated.

Bile acids (BAs), known for digestion, are now recognized as gut hormones regulating metabolism, inflammation, and CNS functions. Targeting BA signaling offers therapeutic potential for metabolic diseases.

Keywords:
Bile acid; Gut microbiota; Farnesoid X receptor; G protein-coupled bile acid receptor; Metabolic disease

More Related Videos

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
08:42

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Published on: November 27, 2016

11.6K
Generation of Organoids from Mouse Extrahepatic Bile Ducts
09:13

Generation of Organoids from Mouse Extrahepatic Bile Ducts

Published on: April 23, 2019

10.6K

Related Experiment Videos

Last Updated: Jan 24, 2026

Laparoscopic Common Bile Duct Exploration Followed by Primary Suture Using a Modified Bile Duct Incision
05:36

Laparoscopic Common Bile Duct Exploration Followed by Primary Suture Using a Modified Bile Duct Incision

Published on: May 2, 2025

650
Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
08:42

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Published on: November 27, 2016

11.6K
Generation of Organoids from Mouse Extrahepatic Bile Ducts
09:13

Generation of Organoids from Mouse Extrahepatic Bile Ducts

Published on: April 23, 2019

10.6K

Area of Science:

  • Endocrinology
  • Gastroenterology
  • Metabolic research

Background:

  • Bile acids (BAs) traditionally function as detergents crucial for lipid digestion and absorption.
  • Emerging research highlights BAs as signaling molecules with extensive physiological and pathological roles.
  • BAs interact closely with gut microbiota, influencing their functions and systemic effects.

Purpose of the Study:

  • To review recent advancements in bile acid research, emphasizing translational applications.
  • To explore the multifaceted roles of bile acids beyond lipid digestion.
  • To discuss the therapeutic potential of targeting bile acid signaling pathways.

Main Methods:

  • Literature review of recent studies on bile acid biology and signaling.
  • Analysis of research on the physiological and pathological roles of bile acids.
  • Examination of therapeutic strategies targeting bile acid signaling.

Main Results:

  • Bile acids act as hormones modulating glucose/lipid metabolism, energy expenditure, inflammation, and CNS activity.
  • BAs are involved in cholesterol homeostasis, enterohepatic protection, and liver regeneration.
  • Signaling pathways mediated by nuclear and G protein-coupled receptors are key to BA actions.

Conclusions:

  • Bile acid signaling represents a promising therapeutic target for metabolic diseases.
  • Pharmacological agents and bariatric surgery show efficacy by modulating BA signaling.
  • Further research into bile acid biology holds significant translational potential.