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Updated: Jan 24, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Catalytic Diastereo- and Enantioselective Synthesis of 2-Imidazolinones
Pablo Martínez-Pardo1, Gonzalo Blay1, Alba Escrivá-Palomo1
1Departament de Química Orgànica, Facultat de Química , Universitat de València , C/Dr. Moliner 50 , 46100 - Burjassot , Spain.
Abstract:
Chiral cyclic ureas (2-imidazolinones) were prepared by the reaction of nitrones and isocyanoacetate esters using a multicatalytic system that combines a bifunctional Brønsted base-squaramide organocatalyst and Ag+ as a Lewis acid. The reaction could be achieved with a range of nitrones derived from aryl- and cycloalkylaldehydes with moderate diastereo- and good enantioselectivity. A plausible mechanism involving an initial formal [3 + 3] cycloaddition of the nitrone and isocyanoacetate ester, followed by rearrangement to an aminoisocyanate and cyclization to the imidazolinone, is proposed.
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