Major trials in coronary intervention from 2018.

Area of Science:

• Cardiology
• Interventional Cardiology
• Clinical Trials

Background:

• Coronary intervention is a rapidly evolving field.
• Clinical trials provide crucial data for treatment advancements.

Purpose of the Study:

• To review major 2018 clinical trials in coronary intervention.
• To cover lesion assessment, stent design, acute coronary syndromes (ACSs), and chronic total occlusion (CTO) interventions.

Main Methods:

• Review of major clinical trials published in 2018.
• Analysis of studies focusing on intracoronary imaging, hemodynamic assessment, drug-coated balloons (DCBs), bioresorbable scaffolds, and revascularization strategies.

Main Results:

• Intracoronary imaging and hemodynamic assessment improve outcomes.
• Conflicting data exists on DCB versus everolimus-eluting stents for in-stent restenosis.
• The ABSORB IV trial showed promise for bioresorbable scaffolds with technique modifications.
• Data on complete versus infarct-related revascularization in ACS remains conflicting.
• The EUROCTO study demonstrated symptomatic benefit for CTO revascularization.

Conclusions:

• 2018 trials influenced updated clinical guidelines.
• Advanced lesion assessment is beneficial in coronary intervention.
• Further research is needed for optimal DCB use and ACS revascularization strategies.
• CTO revascularization offers symptomatic benefits.