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Updated: Jan 24, 2026
06:01
A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
Published on: July 6, 2017
9.9K
The close interrelation between colorectal cancer, infection and microbiota
Edouard Massaut1, Barbara Hendlisz2, Jean A Klastersky2
1Service de Chirurgie, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg.
Current Opinion in Oncology
|May 16, 2019
Summary
Clinical infections may indicate hidden colorectal cancer, and post-surgery infections can worsen survival. The gut microbiota
Area of Science:
- Gastroenterology
- Oncology
- Microbiology
Background:
- Clinical infections like bacteremia and cellulitis may serve as indicators for occult colorectal cancer.
- Postoperative infections can negatively impact long-term survival rates following colorectal cancer surgery.
Purpose of the Study:
- To review recent literature on the link between clinical infection and colorectal cancer.
- To investigate the diagnostic role of occult infections in colorectal cancer.
- To assess the impact of infection on oncological outcomes and the role of gut microbiota in colorectal cancer development.
Main Methods:
- Literature review of studies published within the last two years.
- Critical discussion of existing conclusions, focusing on recent findings.
- Synthesis of evidence regarding infection as a colorectal cancer marker and microbiota's role.
Main Results:
- Recent data largely support previous findings on the association between infection and colorectal cancer.
- Infections, including bacteremia and cellulitis, can be surrogates for occult colorectal cancer.
- Postoperative complications pose a risk to long-term survival after curative surgery for colorectal cancer.
Conclusions:
- The relationship between clinical infection and colorectal cancer requires further investigation.
- The gut microbiota's role in colorectal cancer oncogenesis is a significant area for future research.
- Identifying and managing infections in colorectal cancer patients may improve outcomes.
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