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Updated: Jan 24, 2026

Plaquing of Herpes Simplex Viruses
Published on: November 5, 2021
Vegetative chronic genital herpes with satisfactory response to imiquimod
Stella Meireles Siqueira1, Bruna Barroso Gonçalves1, Julia Bozetti Loss1
1Dermatology Service, Universidade Federal Fluminense, Niterói (RJ), Brazil.
Abstract:
Vegetative chronic genital herpes is an atypical presentation of herpes simplex 2 that it is usually seen in patients coinfected with human immunodeficiency virus. Clinically, it is characterized by extensive ulcers that evolve to chronification and hypertrophic pseudotumor forms. Antiviral drugs are recommended for the treatment, and acyclovir is the most used one. Foscarnet is the treatment of choice to resistant cases, although treatment failure has been reported. We report a male patient, previously diagnosed with human immunodeficiency virus who developed vegetative chronic genital herpes resistant to acyclovir and successfully treated with imiquimod.
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