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Published on: February 13, 2013
Essential thrombocythaemia treated with recombinant interferon: 'real world' United Kingdom referral centre
Joana Desterro1,2, Donal P McLornan1,3, Natalia Curto Garcia1,3
1Department of Haematology, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
Abstract:
Standard first-line therapy choice for essential thrombocythaemia (ET) requiring cytoreduction, supported by randomized trials, is low-dose aspirin with hydroxycarbamide, but the role of recombinant interferon-alfa (IFNα)-2a/2b and pegylated (PEG)-IFN-α-2a/2b is increasingly highlighted. Longer-term outcome data, however, remains somewhat scarce, particularly in the 'real world'. We hereby report on a large, well-annotated cohort of ET patients from a single referral centre undergoing therapy with either IFNα or (PEG)-IFN-α-2a/2b and demonstrate high rates of complete haematological responses, good tolerability and safety, low rates of thromboembolic events in compliant patients and confirm feasibility of long-term therapy in a significant proportion of patients.
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