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Related Experiment Video

Updated: Jan 24, 2026

Investigation into Deep Breathing through Measurement of Ventilatory Parameters and Observation of Breathing Patterns
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Regulation of breathing pattern by IL-10.

Charoula Eleni Giannakopoulou1, Adamantia Sotiriou1, Maria Dettoraki1

  • 1Department of Critical Care and Pulmonary Services and Marianthi Simou Applied Biomedical Research and Training Center, University of Athens Medical School , Athens , Greece.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
|May 16, 2019
PubMed
Summary

Interleukin-10 (IL-10) influences breathing control. Studies show IL-10 administration promotes slower, deeper breathing patterns, while IL-10 knockout mice exhibit altered respiratory rates.

Keywords:
control of breathinginterleukin-10whole body plethysmography

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Area of Science:

  • Respiratory Physiology
  • Immunology
  • Neuroscience

Background:

  • Proinflammatory cytokines, such as interleukin-1 beta (IL-1β), are known to impact respiratory control.
  • The role of anti-inflammatory cytokines, specifically interleukin-10 (IL-10), in regulating breathing patterns remains less understood.

Purpose of the Study:

  • To investigate the effect of the anti-inflammatory cytokine IL-10 on the control of breathing.
  • To compare respiratory function between IL-10 knockout mice and wild-type mice under various gas challenges.

Main Methods:

  • Utilized IL-10 knockout (IL-10-/-) and wild-type (IL-10+/+) mice (n=10 per group) for respiratory function assessment via whole-body plethysmography.
  • Exposed mice to hyperoxic hypercapnia, normoxic hypercapnia, hypoxic hypercapnia, and hypoxic normocapnia gas mixtures.
  • Administered recombinant mouse IL-10 (rIL-10) intraperitoneally to wild-type mice and to neonatal rat medullary slices in vitro.

Main Results:

  • IL-10-/- mice displayed significantly increased respiratory frequency and reduced tidal volume compared to wild-type mice across all gas conditions.
  • Minute ventilation was lower in IL-10-/- mice, and their rapid shallow breathing index was significantly higher than in wild-type mice.
  • Intraperitoneal rIL-10 administration in wild-type mice led to decreased respiratory rate and increased tidal volume; in vitro medullary slice experiments showed no effect on rhythmicity.

Conclusions:

  • IL-10 appears to play a role in modulating breathing patterns, potentially promoting a slower and deeper breathing profile.
  • The findings suggest that IL-10 influences respiratory control mechanisms, contrasting with the effects of proinflammatory cytokines.