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Effects of Second-Hand Smoke on Pancreatitis in Children

Cortney R Ballengee, Peter Brooks1, Traci Leong

  • 1Department of Emergency Medicine, Eastern Virginia Medical School, Norfolk, VA.

Pancreas
|May 16, 2019
PubMed

Insights

Second-hand smoke exposure is linked to increased hospital admissions and longer stays for pediatric pancreatitis. Children with cystic fibrosis transmembrane conductance regulator (CFTR) mutations may face higher admission risks.

Area of Science:

  • Pediatric Gastroenterology
  • Environmental Health
  • Genetic Disorders

Background:

  • Pediatric pancreatitis incidence is rising, with limited understanding of its risk factors.
  • Adult pancreatitis risk is associated with smoking, which impacts CFTR function.
  • Investigating passive smoke exposure in children with pancreatitis is crucial.

Purpose of the Study:

  • To evaluate the effects of passive smoke exposure on pediatric pancreatitis outcomes.
  • To compare disease severity based on smoke exposure levels (none, indoor, outdoor).
  • To assess the role of CFTR mutations in pediatric pancreatitis severity.

Main Methods:

  • Retrospective chart review of 134 pediatric pancreatitis patients over 5 years.
  • Data collected included demographics, pancreatitis etiology, hospitalizations, and length of stay (LOS).
  • Smoking exposure was assessed via telephone query, categorizing patients into no, outdoor, or indoor exposure groups.

Main Results:

  • Indoor smoke exposure was associated with significantly higher average hospital admissions (P=0.038) and LOS (P=0.004).
  • Patients with CFTR mutations had significantly higher average hospital admissions (P≤0.001) compared to those without.
  • No significant difference in admissions or LOS was noted between outdoor and no smoke exposure groups.

Conclusions:

  • Passive smoke exposure, particularly indoor, may exacerbate pediatric pancreatitis, leading to increased hospitalizations and LOS.
  • Children with identified CFTR mutations appear to have a higher risk of hospital admissions for pancreatitis.
  • Further research is warranted to elucidate the mechanisms linking smoke exposure and CFTR mutations to pancreatitis severity.
Abstract

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