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[Relationship between plasma miR-126 and coronary slow flow phenomenon]
1Department of Cardiology, the First People's Hospital of Shangqiu, Shangqiu 476000, China.
Zhonghua Yi Xue Za Zhi
|May 16, 2019
Summary
Plasma miR-126 levels are significantly higher in patients with coronary slow flow (CSF). This microRNA is a potential independent risk factor and predictor for the CSF phenomenon, offering new diagnostic avenues.
Area of Science:
- Cardiology
- Molecular Biology
- Biomarker Discovery
Background:
- Coronary slow flow (CSF) is a microvascular dysfunction affecting blood flow in coronary arteries.
- Identifying reliable biomarkers for CSF is crucial for early diagnosis and management.
- MicroRNAs (miRNAs) are increasingly recognized as potential diagnostic and prognostic indicators in cardiovascular diseases.
Purpose of the Study:
- To investigate the association between plasma miR-126 levels and the presence of the coronary slow flow (CSF) phenomenon.
- To evaluate the potential of miR-126 as a diagnostic biomarker for CSF.
- To explore the relationship between miR-126, hs-CRP, and CSF severity.
Main Methods:
- A case-control study involving 109 patients undergoing coronary angiography.
- Plasma miR-126 expression was quantified using real-time quantitative PCR (RT-qPCR).
- Clinical data, including TIMI frame counts and hs-CRP levels, were collected and analyzed.
Main Results:
- Patients with CSF exhibited significantly higher plasma miR-126 levels compared to controls.
- Plasma miR-126 levels were positively correlated with TIMI frame counts and hs-CRP levels.
- Logistic regression identified miR-126 as an independent risk factor for CSF, with an AUC of 0.661 for prediction.
Conclusions:
- Plasma miR-126 is significantly elevated in patients with coronary slow flow.
- miR-126 demonstrates potential as a valuable predictive biomarker for the coronary slow flow phenomenon.
- These findings suggest miR-126's role in the pathophysiology of CSF and its utility in clinical diagnostics.
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