Changes of cerebral regional oxygen saturation during pneumoperitoneum and Trendelenburg position under propofol...

We evaluated the change of cerebral regional tissue oxygen saturation (rSO₂) along with the pneumoperitoneum and the Trendelenburg position. We also assessed the relationship between the change of rSO₂ and the changes of mean arterial blood pressure (MAP), heart rate (HR), arterial carbon dioxide tension (PaCO₂), arterial oxygen tension (PaO₂), or arterial oxygen saturation (SaO₂).

Forty-one adult patients who underwent a robotic assisted endoscopic prostatic surgery under propofol and remifentanil anesthesia were involved in this study. During the surgery, a pneumoperitoneum was established using carbon dioxide. Measurements of rSO₂, MAP, HR, PaCO₂, PaO₂, and SaO₂ were performed before the pneumoperitoneum (baseline), every 5 min after the onset of pneumoperitoneum, before the Trendelenburg position. After the onset of the Trendelenburg position, rSO₂, MAP, HR were recorded at 5, 10, 20, 30, 45, and 60 min, and PaCO₂, PaO₂, and SaO₂ were measured at 10, 30, and 60 min.

Before the pneumoperitoneum, left and right rSO₂ were 67.9 ± 6.3% and 68.5 ± 7.0%. Ten minutes after the onset of pneumoperitoneum, significant increase in the rSO₂ was observed (left: 69.6 ± 5.9%, right: 70.6 ± 7.4%). During the Trendelenburg position, the rSO₂ increased initially and peaked at 5 min (left: 72.2 ± 6.5%, right: 73.1 ± 7.6%), then decreased. Multiple regression analysis showed that change of rSO₂ correlated with MAP and PaCO₂.

Pneumoperitoneum and the Trendelenburg position in robotic-assisted endoscopic prostatic surgery did not worsen cerebral oxygenation. Arterial blood pressure is the critical factor in cerebral oxygenation.

Japan Primary Registries Network (JPRN); UMIN-CTR ID; UMIN000026227 (retrospectively registered).