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Beta blockade as adjunctive breast cancer therapy: A review

Sneha Phadke1, Gerald Clamon1

  • 1University of Iowa Carver College of Medicine, Department of Internal Medicine, Division of Hematology, Oncology, and Blood and Marrow Transplantation, 200 Hawkins Drive, Iowa City, IA 52242, United States.

Critical Reviews in Oncology/Hematology
|May 17, 2019
PubMed

Insights

Beta blockers may help treat cancer. Research reviews beta adrenergic blockade as an adjunctive cancer therapy, particularly for breast cancer, showing potential benefits with low toxicity.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Beta adrenergic stimulation influences cancer development and progression.
  • Beta blockers have been investigated for anti-neoplastic effects with inconclusive results.
  • Breast cancer therapies have advanced, but further improvements are needed.

Purpose of the Study:

  • To review the literature on beta blockade as an adjunctive cancer therapy.
  • To focus on the role of beta blockers in breast cancer treatment.

Main Methods:

  • Review of published literature.
  • Analysis of pre-clinical data.
  • Examination of retrospective and observational trials.

Main Results:

  • Pre-clinical evidence suggests beta adrenergic stimulation impacts cancer.
  • Clinical trial data on beta blockers for cancer efficacy is not definitive.
  • Beta blockade shows potential as a low-toxicity adjunct for breast cancer therapy.

Conclusions:

  • Beta adrenergic blockade may serve as an effective addition to standard breast cancer treatments.
  • Further research is warranted to confirm the efficacy of beta blockers in oncology.
  • The potential for minimal toxicity makes beta blockers an attractive area for breast cancer research.
Keywords:
Beta adrenergic receptorsBeta blockerBreast cancerPropranolol

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