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Updated: Jan 24, 2026

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids
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Multidisciplinary expert opinion on the treatment consensus for patients with EGFR mutated NSCLC with brain

Santiago Ponce1, Jordi Bruna2, Oscar Juan3

  • 1Lung Cancer Clinical Research Unit, Hospital Universitario 12 de Octubre, Av. Cordoba, s/n, 28041 Madrid, Spain.

Critical Reviews in Oncology/Hematology
|May 17, 2019
PubMed

Insights

Patients with EGFR-mutated non-small cell lung cancer (NSCLC) and brain metastases need clear management guidelines. This expert consensus provides recommendations for this specific patient group, addressing a gap in clinical evidence.

Area of Science:

  • Oncology
  • Neurology
  • Medical Research

Background:

  • Epidermal growth factor receptor (EGFR) mutations correlate with increased brain metastases in non-small cell lung cancer (NSCLC).
  • Patients with synchronous brain metastases at diagnosis are often excluded from clinical trials, leading to limited evidence for their management.

Purpose of the Study:

  • To develop an expert opinion consensus on managing EGFR-mutated NSCLC patients with brain metastases.
  • To address the lack of clinical evidence and provide guidance for this specific patient population.

Main Methods:

  • A multidisciplinary group of Spanish oncologists and neuro-oncologists convened.
  • The group reached consensus on 26 recommendations and 20 conclusions across 7 areas.
  • A first-line treatment algorithm was developed.

Main Results:

  • The consensus addresses 21 key questions regarding the management of EGFR-mutated NSCLC with brain metastases.
  • The developed algorithm offers a structured approach to first-line treatment decisions.
  • The recommendations cover various aspects of care for this complex patient group.

Conclusions:

  • Expert consensus provides crucial guidance for managing EGFR-mutated NSCLC with brain metastases.
  • The recommendations and algorithm aim to improve clinical decision-making and patient outcomes.
  • Further research is warranted to validate these expert opinions in clinical practice.
Keywords:
Brain metastasesConsensusDiagnosisEGFR mutationManagementNSCLCRecommendationTreatment

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