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Updated: Jan 24, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
Prognostic Impact of Proximal Versus Distal Localization in Extremity Long Bone Osteosarcomas
Kjetil Berner1, Øyvind S Bruland2,3
1Department of Oncology, Oslo University Hospital, The Norwegian Radium Hospital, Oslo, Norway kjetil.berner@ous-hf.no.
Background/Aim:
This study aimed to identify the prognostic factors and outcomes of osteosarcoma (OS) located in proximal versus distal extremity long bones.
Patients And Methods:
A nationwide cohort comprising all Norwegian high-grade OSs in extremity long bones between 1982 and 2009 was investigated.
Results:
The univariate analysis results identified no significant differences in survival between patients with OS in proximal long bones (101 cases) as a group in comparison to patients with OS in the distal part of these bones (120 cases). However, proximal femur and primary metastasis were both independent adverse prognostic factors for sarcoma-specific survival in multivariate analyses, while elevated LDH and secondary OS were inferior prognostic factors for event-free survival. Adequate surgery and chemotherapy had a positive impact on survival.
Conclusion:
OS of the proximal femur had an unfavorable outcome in comparison to OS in other anatomical locations in extremity long bones.
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