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Related Experiment Video

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Deep Brain Stimulation with Simultaneous fMRI in Rodents

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Published on: February 15, 2014

Malignant deep brain stimulator withdrawal syndrome.

Jehad Azar¹, Hila Elinav², Rifaat Safadi²

¹Internal Medicine, St. Vincent Charity Medical Center, Cleveland, Ohio, USA.

BMJ Case Reports

|May 17, 2019

Summary

Parkinsonism-hyperpyrexia syndrome (PHS) is a critical neurological emergency. This case highlights PHS triggered by deep brain stimulator battery depletion, successfully treated with medication and battery replacement.

Keywords:

neuroendocrinology neurology (drugs and medicines)

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Area of Science:

Neurology
Critical Care Medicine

Background:

Parkinsonism-hyperpyrexia syndrome (PHS) is a rare, life-threatening neurological emergency.
PHS often mimics neuroleptic malignant syndrome and is typically triggered by anti-Parkinsonian medication withdrawal.

Observation:

This report details a case of PHS presenting as sepsis.
The patient experienced PHS due to deep brain stimulator (DBS) battery depletion, a rare cause.

Findings:

The syndrome manifested with systemic inflammatory response syndrome, muscle rigidity, autonomic instability, hyperpyrexia, confusion, diaphoresis, and elevated creatine phosphokinase.
Successful treatment involved dopamine agonists, intravenous fluids, and DBS battery replacement.

Implications:

This case underscores DBS battery depletion as a potential, albeit rare, cause of PHS.
Early recognition and intervention, including device maintenance, are crucial for managing PHS in DBS patients.