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Related Experiment Videos

Monoclonal IgM and chronic urticaria: two cases.

M S Doutre, C Beylot, P Bioulac

    Annals of Allergy
    |June 1, 1987
    PubMed
    Summary

    This study describes two patients with chronic urticaria and monoclonal immunoglobulin M (IgM) without signs of lymphoid disease. These findings add to a small group of similar cases, suggesting a distinct clinical entity.

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    Area of Science:

    • Immunology
    • Dermatology
    • Hematology

    Background:

    • Chronic urticaria is a common dermatological condition.
    • Monoclonal gammopathies can be associated with various clinical manifestations.
    • The co-occurrence of chronic urticaria and monoclonal IgM without lymphoid disease is rare.

    Observation:

    • Two new cases of chronic urticaria associated with serum monoclonal IgM were identified.
    • These patients showed no evidence of underlying lymphoid malignancy.
    • Previously reported cases exhibited similar clinical, histological, and immunological features.

    Findings:

    • The observed cases suggest a distinct clinicopathological entity characterized by chronic urticaria and monoclonal IgM.
    • The absence of detectable lymphoid disease in these patients is a key feature.
    • Immunological investigations revealed specific patterns in these patients.

    Implications:

    • Understanding the pathogenesis of this rare condition is crucial for accurate diagnosis and management.
    • Further research is needed to elucidate the mechanisms linking monoclonal IgM to chronic urticaria.
    • This entity may represent a unique B-cell dyscrasia or an autoimmune phenomenon.

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