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Related Experiment Video

Updated: Jan 24, 2026

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Published on: June 2, 2023

Adenosine-Functionalized Biodegradable PLA-b-PEG Nanoparticles Ameliorate Osteoarthritis in Rats.

Xiuling Liu¹, Carmen Corciulo², Stephanie Arabagian¹

¹Department of Chemical and Biomolecular Science and Engineering, NYU Tandon School of Engineering, 6 Metrotech Center, New York, NY, 11201, USA.

Scientific Reports

|May 17, 2019

Summary

Attaching adenosine to biodegradable nanoparticles extended its therapeutic effect. Adenosine nanoparticles prevented osteoarthritis in a rat model, showing promise for prolonged drug delivery.

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Published on: June 23, 2020

Area of Science:

Biomaterials Science
Nanotechnology
Pharmacology

Background:

Short biologic half-lives of small molecules limit therapeutic applications.
Nanoparticle conjugation offers a strategy to extend drug half-lives.
Adenosine receptor agonists are important therapeutic targets.

Purpose of the Study:

To synthesize and evaluate targeted polymeric nanoparticles conjugated with adenosine.
To investigate the potential of these nanoparticles as adenosine receptor agonists.
To assess the in vivo efficacy of adenosine nanoparticles in a post-traumatic osteoarthritis model.

Main Methods:

Synthesis of PLA-b-PEG block copolymers conjugated to adenosine using click chemistry.
Testing nanoparticle activity via cAMP increase assays in RAW264.7 macrophage cells.
In vivo evaluation of adenosine nanoparticles in a rat model of post-traumatic osteoarthritis.

Main Results:

Adenosine-conjugated nanoparticles (A-3',4'-OH-TPN2) stimulated cAMP increases, indicating adenosine receptor agonism.
The observed cAMP increases were blocked by selective adenosine A2A and A2B receptor antagonists.
Intra-articular injection of adenosine nanoparticles prevented osteoarthritis development in rats.

Conclusions:

Attachment of adenosine to biodegradable nanoparticles provides a novel approach for prolonged therapeutic effects.
Adenosine nanoparticles demonstrate potential for treating conditions like osteoarthritis.
This strategy enhances the therapeutic utility of small molecules by extending their half-lives.