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Influence of β-Globin Haplotypes on Oxidative Stress, Antioxidant Capacity and Inflammation in Sickle Cell Patients

Sanjana Bhagat1, Amar Singh Thakur2

  • 1Department of Biotechnology, Govt. N.P.G. College of Science Raipur, GE Road, Raipur, Chhattisgarh 492010 India.

Indian Journal of Clinical Biochemistry : IJCB
|May 17, 2019
PubMed

Insights

Sickle cell disease (SCD) patients with the Arab-Indian beta-globin gene haplotype show lower inflammation and oxidative stress. This haplotype is linked to higher antioxidant capacity and fetal hemoglobin (HbF) levels in Chhattisgarh.

Area of Science:

  • Genetics and Molecular Biology
  • Hematology
  • Biochemistry

Background:

  • Sickle cell disease (SCD) is a genetic blood disorder with varying clinical severity.
  • Beta-globin gene haplotypes are known to influence SCD phenotype.
  • Oxidative stress, inflammation, and antioxidant status are key factors in SCD pathogenesis.

Purpose of the Study:

  • To investigate the frequency of beta-globin gene haplotypes in SCD patients from Chhattisgarh.
  • To determine the influence of these haplotypes on oxidative stress, antioxidant levels, and inflammation.

Main Methods:

  • Serum levels of total antioxidant capacity, oxidative stress markers (MDA), and inflammation markers (CRP) were measured.
  • Hemoglobin F (HbF) levels were also assessed.
  • Comparison of biochemical markers across different beta-globin gene haplotypes (Arab-Indian, Bantu, and others).

Main Results:

  • The Arab-Indian haplotype was associated with significantly lower serum CRP and MDA levels (p < 0.0001) compared to Bantu and other haplotypes.
  • Patients with the Arab-Indian haplotype exhibited significantly higher antioxidant capacity and HbF levels.
  • These findings suggest a protective role for the Arab-Indian haplotype.

Conclusions:

  • Beta-globin gene haplotypes play a significant role in modulating the severity of sickle cell disease.
  • The Arab-Indian haplotype appears to be associated with a less severe phenotype in SCD patients in Chhattisgarh.
  • Targeting haplotype-specific mechanisms could offer new therapeutic strategies for SCD.

Keywords:
HaplotypeHbF levelInflammationOxidative stressSickle cell disease

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