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[Bone metastasis from renal cell carcinoma].

K Matsumoto

    Gan to Kagaku Ryoho. Cancer & Chemotherapy
    |May 1, 1987
    PubMed
    Summary

    This study identified specific renal cell carcinoma subtypes and high-grade tumors associated with bone metastasis. Current therapies showed limited improvement for patients with metastatic bone lesions.

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    Ki-67 antibody labeling index in colorectal carcinoma.

    Journal of clinical gastroenterology·1992

    Area of Science:

    • Oncology
    • Pathology

    Context:

    • Renal cell carcinoma (RCC) is a significant malignancy.
    • Bone metastasis is a common and serious complication of advanced RCC.
    • Understanding risk factors for bone metastasis is crucial for patient management.

    Purpose:

    • To investigate histopathological risk factors for bone metastasis in renal cell carcinoma.
    • To evaluate the efficacy of radiation and infusion therapies for bone metastases in RCC patients.

    Summary:

    • This study analyzed 124 primary renal cell carcinoma cases, identifying 38 with bone metastasis.
    • Histopathological features, including alveolar, solid (sarcomatoid), and mixed types, granular cell subtype, and high nuclear grades (3 and 4), were associated with increased bone metastasis risk.
    • Radiation therapy and tumor artery infusion therapy demonstrated limited efficacy in improving objective findings for metastatic bone lesions.

    Impact:

    • Identifies specific RCC subtypes and grades predictive of bone metastasis.
    • Highlights limitations of current therapeutic approaches for metastatic bone lesions in RCC.
    • Informs prognostic assessments and potential future research directions for managing RCC bone metastases.

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