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Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
03:55

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

953

Optimal use of lenvatinib in the treatment of advanced thyroid cancer

Shunji Takahashi1, Naomi Kiyota2, Makoto Tahara3

  • 11Department of Medical Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550 Japan.

Cancers of the Head & Neck
|May 17, 2019
PubMed

Insights

Lenvatinib, a kinase inhibitor, shows efficacy in advanced thyroid cancer by stabilizing disease. Careful management of side effects is crucial for successful treatment continuation and improved outcomes.

Area of Science:

  • Oncology
  • Pharmacology
  • Clinical Trials

Background:

  • Multitargeted kinase inhibitors (MKIs) offer a significant advancement in treating progressive, metastatic thyroid cancer.
  • Lenvatinib, an MKI, targets multiple receptors including VEGFR, FGFR, PDGFR, c-Kit, and RET, demonstrating efficacy in stabilizing disease.

Purpose of the Study:

  • To review the clinical efficacy and safety of MKIs in advanced thyroid cancer based on pivotal Phase III trials.
  • To discuss common adverse events associated with lenvatinib and strategies for their management, including dose modification.

Main Methods:

  • Review of pivotal Phase III clinical trials evaluating MKIs in advanced thyroid cancer.
  • Focus on data from a Japanese subanalysis of the SELECT trial and a post-marketing study in Japan.
  • Analysis of adverse events and management strategies for lenvatinib therapy.

Main Results:

  • Lenvatinib demonstrates efficacy in stabilizing previously progressive thyroid cancer, with potential overall survival benefits.
  • Adverse event profiles are similar to other MKIs and require careful monitoring and management.
  • Data from Japanese patient studies support lenvatinib's role in advanced differentiated thyroid cancer.

Conclusions:

  • Lenvatinib is a valuable treatment option for advanced differentiated thyroid cancer.
  • Effective management of adverse events through supportive care and dose adjustments is essential for treatment continuation.
  • MKIs represent a key therapeutic strategy for advanced thyroid cancer, necessitating a balanced approach to efficacy and safety.
Keywords:
Adverse eventLenvatinibMultitargeted kinase inhibitorThyroid cancerVascular endothelial growth factor receptor

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