Locally advanced high-risk HPV related oropharyngeal squamous cell carcinoma (OPSCC); have we forgotten it is a
Nabil F Saba1, Shuli Li2, Zain A Hussain3
11Winship Cancer Institute, Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, 1365Clifton Road, building C, Atlanta, GA 30322 USA.
Abstract:
HPV related OPSCC has a distinct behavior and improved outcome. As immunotherapy has recently evolved into a new standard for advanced (SCCHN), trials for high-risk SCCHN have trended to encompass both HPV related and unrelated diseases. In this invited editorial, we question the wisdom of this approach and argue for the design of trials focused specifically on HPV related locally advanced oropharyngeal squamous cell carcinoma as a unique disease entity.
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