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Incidentally Diagnosed Alport Syndrome in a Patient with Drug-Induced Vasculitis
D Lai1,2, N Dave1,2,3, R Raghavan1,2,3
1Baylor College of Medicine, Houston, TX 77030, USA.
Abstract:
A 53-year-old woman is admitted with a serum creatinine of 16 mg/dl. Seven months earlier, she was diagnosed with heart failure and started on several medications, including Hydralazine. Laboratory studies revealed the presence of dual Anti-Neutrophil Cytoplasmic Antibodies (anti-MPO and anti-PR3), anti-nuclear and anti-histone antibodies. The clinical diagnosis was Drug-Induced ANCA Vasculitis (DIAV). Kidney histology, however, did not reveal crescents, but showed characteristic features of Alport's syndrome.
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