Ventriculoperitoneal Shunt Infection Caused by Enterococcus gallinarum in a Pediatric Patient: A Case Report

Kacie Clark1, Deborah Maka2

  • 1Department of Pharmacy, Florida Hospital Orlando, Orlando, Florida, United States.

Insights

Enterococcus gallinarum, a bacterium with natural vancomycin resistance, can cause ventriculoperitoneal shunt infections in children. Prompt antibiotic treatment led to a full recovery in a pediatric case.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pediatrics

Background:

  • Enterococcus gallinarum is a Gram-positive bacterium commonly found in the gut.
  • This species exhibits intrinsic resistance to vancomycin, a critical antibiotic.
  • Ventriculoperitoneal (VP) shunts are used to treat hydrocephalus in children.

Observation:

  • A 4-year-old female patient developed a VP shunt infection.
  • Cerebrospinal fluid (CSF) cultures identified Enterococcus gallinarum as the causative agent.
  • The infection presented as a complication of VP shunt placement.

Findings:

  • The patient was treated with ampicillin and gentamicin, demonstrating synergistic activity.
  • A 16-day antibiotic course resulted in negative CSF and blood cultures.
  • Complete clinical cure of the ventriculoperitoneal shunt infection was achieved.

Implications:

  • This case highlights the importance of recognizing vancomycin-resistant Enterococcus species in clinical practice.
  • Prompt and appropriate antibiotic therapy is crucial for managing shunt infections.
  • Increased awareness of Enterococcus gallinarum's resistance patterns is necessary for effective pediatric infectious disease management.

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
214
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
276
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
200
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
261
Shunt Admittances01:26

Shunt Admittances

Shunt admittances play a crucial role in the analysis of transmission lines, particularly for three-phase systems with neutral conductors. When a uniformly charged conductor is positioned above the Earth, it induces an equal but opposite charge on its surface. This interaction creates electric field lines between the conductor and the Earth.
To model this effect, the method of images is employed. This method involves replacing the Earth with an image conductor that mirrors the original...
493
Data Reporting and Recording01:24

Data Reporting and Recording

Reporting and recording are crucial in data documentation. The timely, thorough, and accurate documentation of facts is essential when recording patient data. Failure to record findings during an assessment or interpretation of a problem will result in loss of information and make the patient document unreliable. The reader is left with general impressions if the information is not specific. A recording is documenting data of the individual's health information in a traceable, secure, and...
5.4K