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Challenges with optimizing nutrition in cystic fibrosis
Carla Colombo1,2, Rita Maria Nobili2, Gianfranco Alicandro3
1a Department of Pathophysiology and Transplantation , Università degli Studi di Milano , Milan , Italy.
Optimizing nutrition is key for cystic fibrosis (CF) patients, but many still struggle with growth. This review highlights challenges in CF nutritional therapy, including energy balance and enzyme replacement, to improve patient outcomes.
Area of Science:
- Nutritional Science
- Gastroenterology
- Pulmonology
Background:
- Optimizing nutrition is crucial for cystic fibrosis (CF) patients, impacting pulmonary function and survival.
- A significant number of CF patients do not achieve normal growth and nutritional status despite current therapies.
Purpose of the Study:
- To review current challenges in effective nutritional therapy for CF.
- To focus on energy imbalance, dietary composition, adherence, enzyme replacement, and modulator effects in CF.
Main Methods:
- Literature review of current challenges in CF nutritional therapy.
- Analysis of issues related to energy balance, diet, adherence, pancreatic enzyme replacement therapy (PERT), and CFTR modulator impacts.
Main Results:
- CF patients face persistent challenges in achieving optimal nutritional status.
- Key issues include energy imbalance, suboptimal dietary composition, poor adherence, and the need for improved PERT.
Conclusions:
- CF requires a personalized nutritional approach with careful energy balance evaluation.
- Evidence-based dietary recommendations are needed, considering overweight, diabetes, and fatty acid effects.
- Further research into novel PERT formulations is essential.
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