Related Experiment Video
Updated: Jan 24, 2026

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds
Published on: August 21, 2021
Formulation and characterization of glibenclamide and quercetin-loaded chitosan nanogels targeting skin permeation
Dinesh Kumar Chellappan1, Neoh Jia Yee2, Bhalqish Jeet Kaur Ambar Jeet Singh2
1Department of Life Sciences, International Medical University, Kuala Lumpur, Malaysia 57000.
Abstract:
Aim: Our aim was to develop and characterize a nanogel formulation containing both glibenclamide and quercetin and to explore the permeation profile of this combination. Methods: Drug-loaded nanogel was prepared by ionic gelation. In addition, optimum encapsulation efficiencies of glibenclamide and quercetin were also obtained. The average nanoparticle size at optimum conditions was determined by Zetasizer. Results: The particle size of the nanogel was found to be 370.4 ± 4.78 nm with a polydispersity index of 0.528 ± 0.04, while the λ potential was positive in a range of 17.6 to 24.8 mV. The percentage cumulative drug release also showed favorable findings. Conclusion: The chitosan nanogel could be a potential alternative for delivering glibenclamide and quercetin through skin.
Related Concept Videos
Insulin Formulations: Types and Delivery
Short-acting insulins are divided into...
Formulating and Validating Nursing Diagnosis II
Risk nursing diagnoses represent clinical judgments of an individual, family, or community more vulnerable to developing the health problem than others...
Moment of a Force: Scalar Formulation
Consider a simple example of a flywheel being rotated about a point, O, by applying a force to it. In this case, the moment arm is the perpendicular distance between the point O and the line of action of the force. The...
Resultant Moment: Scalar Formulation
To determine the resultant moment, the moments caused by all the forces in a system in the x-y plane are considered. Positive moments are typically...
Moment of a Force: Vector Formulation
The vector formulation of the moment of force is the cross-product of the position and force vectors. The...
Formulating and Validating Nursing Diagnosis I
There are thirteen domains...

