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Fish oil in angina pectoris.

S D Kristensen, E B Schmidt, H R Andersen

Atherosclerosis

|March 1, 1987

Summary

Fish oil supplementation for 12 weeks reduced angina attacks but wasn't significantly better than placebo. Further research is needed due to small sample size, though fish oil did impact platelet aggregation.

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Area of Science:

Cardiology
Nutritional Science
Pharmacology

Background:

Stable angina pectoris is a common cardiovascular condition.
Current treatments aim to manage symptoms and reduce cardiac events.
The role of omega-3 fatty acids, particularly from fish oil, in cardiovascular health is an area of ongoing research.

Purpose of the Study:

To evaluate the effect of 12-week fish oil supplementation on anginal attacks and glyceryltrinitrate consumption in patients with stable angina pectoris.
To assess the impact of fish oil on platelet aggregation and intraplatelet cyclic AMP levels.

Main Methods:

A randomized, placebo-controlled trial involving 36 patients with stable angina pectoris.
Participants received either fish oil or vegetable oil (placebo) for 12 weeks.
Outcomes measured included the frequency of anginal attacks, glyceryltrinitrate consumption, epinephrine-induced platelet aggregation, and intraplatelet cyclic AMP levels.

Main Results:

Fish oil supplementation led to a decrease in the frequency of anginal attacks, although this was not statistically superior to the placebo group.
A significant inhibition of epinephrine-induced platelet aggregation was observed in the fish oil group.
Fish oil supplementation significantly increased intraplatelet cyclic AMP levels.

Conclusions:

While fish oil showed a trend towards reducing angina frequency, it did not reach statistical significance compared to placebo in this study.
The study highlights a potential risk of overlooking a clinically meaningful reduction in angina due to small sample size and high variability.
Fish oil demonstrates a significant biological effect on platelet function and cyclic AMP levels, suggesting potential cardioprotective mechanisms.

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