Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interferon-gamma: involvement in human disease.

E N Wardle

    British Journal of Hospital Medicine
    |June 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Interferon-gamma is a crucial mediator of host resistance against infections. This cytokine plays a vital role in managing susceptibility to various infectious agents.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    FRACTURES OF BOTH BONES OF THE LEG.

    British medical journal·2010
    Same author

    Pathogenesis of acute renal failure: shock-kidneys.

    Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia·2008
    Same author

    Understanding immunoglobulin IgA nephropathy.

    Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia·2008
    Same author

    Advances in the pathogenesis of glomerulonephritides.

    Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia·2008
    Same author

    Ways of treating IgA nephropathies.

    Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia·2008
    Same author

    Coxibs and caution.

    Journal of the Royal Society of Medicine·2005

    Area of Science:

    • Immunology
    • Infectious Diseases
    • Molecular Biology

    Background:

    • Host susceptibility to infections is a complex phenomenon influenced by numerous factors.
    • The immune system employs various mechanisms to combat pathogens.
    • Cytokines are critical signaling molecules in immune responses.

    Purpose of the Study:

    • To discuss the multifaceted nature of infection susceptibility.
    • To highlight the central role of interferon-gamma in host defense.
    • To elucidate the mechanisms by which interferon-gamma mediates resistance.

    Main Methods:

    • Literature review of studies on host-pathogen interactions.
    • Analysis of immunological data related to cytokine function.
    • Examination of clinical and experimental evidence on infection outcomes.

    Related Experiment Videos

    Main Results:

    • Interferon-gamma (IFN-γ) is identified as a key mediator of resistance across diverse infectious scenarios.
    • IFN-γ modulates cellular and humoral immune responses essential for pathogen clearance.
    • Deficiencies in IFN-γ signaling correlate with increased susceptibility to specific infections.

    Conclusions:

    • Interferon-gamma is indispensable for effective host defense against a wide range of infections.
    • Understanding IFN-γ's role is crucial for developing strategies to combat infectious diseases.
    • Targeting or augmenting IFN-γ pathways may offer therapeutic benefits in managing infections.