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Numerical Study and Experimental Verification of Tissue Cryofreezing Based on Flexible Cryoprobe System
1Institute of Biothermal Technology, University of Shanghai for Science and Technology, Shanghai, China.
Cryo Letters
|May 17, 2019
Summary
A new flexible cryoprobe for cancer treatment was developed and validated. This innovative device allows for precise temperature control, ensuring effective diseased tissue destruction while minimizing damage to healthy surrounding tissues.
Area of Science:
- Biomedical Engineering
- Medical Physics
- Oncology
Background:
- Cryosurgery is a valuable treatment for tumors, but accurately measuring temperature profiles for tissue destruction remains challenging.
- Existing methods struggle with precise quantification of spatial temperature, impacting treatment efficacy and safety.
Purpose of the Study:
- To develop and validate a novel flexible cryosurgical probe designed for minimally invasive procedures through natural body cavities.
- To utilize 3D heat transfer modeling and experimental verification to study the design and performance of this flexible cryoprobe.
Main Methods:
- A 3D heat transfer model based on the Pennes equation was created to simulate temperature distribution during cryosurgery.
- In vitro experiments using porcine liver tissue and pathological analysis (TUNEL staining) were conducted for model verification.
Main Results:
- Numerical simulations showed good agreement with experimental measurements for the flexible cryoprobe system.
- Effective tissue destruction was observed within 0-6 mm of the probe, with temperatures reaching -35°C to -40°C.
- Pathological analysis confirmed the efficacy of the flexible cryoprobe in destroying targeted tissue.
Conclusions:
- The flexible cryoprobe system is effective, as demonstrated by numerical simulation and experimental validation.
- The developed 3D heat transfer model serves as a crucial tool for optimizing future flexible cryoprobe designs.
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