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Changes in population-level survival for advanced solid malignancies with new treatment options in the second decade

Dianne Pulte1, Janick Weberpals1, Lina Jansen1

  • 1Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.

Cancer
|May 17, 2019
PubMed
Abstract

Insights

New cancer treatments are improving survival rates for advanced lung adenocarcinoma, melanoma, and breast cancer patients in the general population. These advancements indicate a positive trend for stage IV cancer outcomes.

Area of Science:

  • Oncology
  • Public Health
  • Cancer Research

Background:

  • Advanced solid malignancies pose significant survival challenges.
  • Clinical trials show promise for new treatment options.
  • Population-level impact of these treatments remains largely unquantified.

Observation:

  • The study analyzed survival data for lung adenocarcinoma, melanoma, breast, prostate, and renal cell carcinoma.
  • Kaplan-Meier analysis and hazard ratio models assessed survival trends.
  • Data spanned periods before and after new treatment approvals (2007-2012).

Findings:

  • Two-year survival increased for advanced lung adenocarcinoma, melanoma, and breast cancer.
  • Significant survival gains were noted in younger melanoma patients (15-64 years).
  • Cancer-specific mortality decreased for lung adenocarcinoma, melanoma, and breast cancer.

Implications:

  • Newer treatments are beginning to demonstrate a positive impact on population-level survival for stage IV cancers.
  • These findings highlight the importance of real-world data in evaluating treatment efficacy.
  • Further research is warranted to explore long-term survival benefits and specific treatment contributions.
Keywords:
Kaplan-Meier analysisadenocarcinomamelanomarenal cell carcinomasurvival analysis

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