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Related Experiment Videos

Exaggerated postural vasoconstrictor reflex in Raynaud's phenomenon.

N Olsen, O U Petring, N Rossing

    British Medical Journal (Clinical Research Ed.)
    |May 9, 1987
    PubMed
    Summary
    This summary is machine-generated.

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    Primary Raynaud

    Area of Science:

    • Physiology
    • Vascular Biology
    • Neurology

    Background:

    • Raynaud's phenomenon involves episodic digital vasospasm.
    • Understanding the regulation of finger blood flow is crucial for managing these conditions.

    Purpose of the Study:

    • To investigate central and local regulation of finger capillary blood flow.
    • To compare responses in primary Raynaud's phenomenon and vibration-induced white finger (VWF) to controls.

    Main Methods:

    • Utilized local xenon-133 washout technique to measure digital blood flow.
    • Assessed vasoconstrictor responses to venous stasis and postural changes (lying to sitting).
    • Employed proximal nervous blockade to evaluate reflex involvement.

    Main Results:

    Related Experiment Videos

    • Normal vasoconstrictor response to venous stasis in both Raynaud's and VWF groups.
    • Postural vasoconstriction (sitting) was present in all groups but augmented in Raynaud's and VWF.
    • Nervous blockade abolished postural vasoconstriction, indicating a reflex mechanism.

    Conclusions:

    • Identified central and local postural vasoconstrictor reflexes in normal fingers.
    • Demonstrated sympathetic nervous system hyperreactivity to orthostatic stress in Raynaud's and VWF.
    • Confirmed normal digital arteriolar and postganglionic sympathetic nerve function in these conditions.