Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Machine learning prediction of local control after Gamma Knife radiosurgery to post-resection cavities from brain metastases: a proof-of-concept study.

Journal of neuro-oncology·2026
Same author

Therapeutic Hybrid Intelligence with Neural and Knowledge-based Expert Reasoning for SRS (THINKERS): an AI model for GBM.

Journal of neuro-oncology·2026
Same author

Dose De-escalation in Stereotactic Radiosurgery for Melanoma Brain Metastases in Patients on Concurrent Immunotherapy or Targeted Therapy: A Multicenter Experience.

Neurosurgery·2026
Same author

Beyond tumor control: symptom trajectories and hearing outcomes after contemporary Gamma Knife radiosurgery for vestibular schwannoma.

Journal of neuro-oncology·2026
Same author

Therapeutic Hybrid Intelligence with Neural and Knowledge-based Expert Reasoning for SRS (THINKERS): a mixture-of-experts AI model for vestibular schwannoma.

Journal of neuro-oncology·2026
Same author

Volume-Staged Stereotactic Radiosurgery in Pediatric Patients With Large Brain Arteriovenous Malformations: An International, Multicenter Study.

Neurosurgery·2026

Related Experiment Video

Updated: Jan 24, 2026

Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model
05:12

Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model

Published on: September 4, 2017

11.3K

Leksell Stereotactic Radiosurgery for Cavernous Malformations.

L Dade Lunsford1, Ajay Niranjan2, Hideyuki Kano2

  • 1Center for Image-Guided Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA, lunsfordld@upmc.edu.

Progress in Neurological Surgery
|May 17, 2019
PubMed
Summary

Cavernous malformations (CM), a type of brain vascular malformation, are increasingly detected via MRI. Stereotactic radiosurgery effectively reduces bleeding risk in select high-risk patients.

More Related Videos

Cavernous Nerve Stimulation and Recording of Intracavernous Pressure in a Rat
07:43

Cavernous Nerve Stimulation and Recording of Intracavernous Pressure in a Rat

Published on: April 23, 2018

13.4K
A Patient-Derived Xenograft Model for Venous Malformation
06:51

A Patient-Derived Xenograft Model for Venous Malformation

Published on: June 15, 2020

5.8K

Related Experiment Videos

Last Updated: Jan 24, 2026

Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model
05:12

Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model

Published on: September 4, 2017

11.3K
Cavernous Nerve Stimulation and Recording of Intracavernous Pressure in a Rat
07:43

Cavernous Nerve Stimulation and Recording of Intracavernous Pressure in a Rat

Published on: April 23, 2018

13.4K
A Patient-Derived Xenograft Model for Venous Malformation
06:51

A Patient-Derived Xenograft Model for Venous Malformation

Published on: June 15, 2020

5.8K

Area of Science:

  • Neurology
  • Neurosurgery
  • Radiology

Background:

  • Cavernous malformations (CM) are vascular malformations in the brain.
  • Increased detection due to advanced Magnetic Resonance Imaging (MRI).
  • CM can be solitary or familial, with risks of bleeding.

Purpose of the Study:

  • To evaluate management options for cavernous malformations.
  • To assess the efficacy of Leksell radiosurgery for high-risk CM patients.

Main Methods:

  • Review of cavernous malformation characteristics and detection via MRI.
  • Application of Leksell stereotactic radiosurgery for deep-seated CM.
  • Targeting the hemosiderin rim identified on MRI for radiosurgery planning.

Main Results:

  • The annual risk of bleeding for incidentally detected CM is less than 0.5%.
  • Stereotactic radiosurgery significantly reduces annual bleeding risk from 33% to <0.5% in high-risk patients after a 2-year latency.
  • Radiosurgery is suitable for deep-seated CM not accessible for microsurgery.

Conclusions:

  • Stereotactic radiosurgery is an effective treatment for reducing re-bleeding in selected cavernous malformation patients.
  • Management decisions for CM should consider bleeding risk and surgical accessibility.
  • Radiosurgery offers a viable alternative for deep-seated CM where microsurgery is not feasible.