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Dose-response relationship between higher serum calcium level and higher prevalence of hyperuricemia: A

Zhichen Liu1, Xiang Ding1, Jing Wu2

  • 1Department of Orthopaedics, Xiangya Hospital.

Medicine
|May 18, 2019
PubMed

Insights

Higher serum calcium levels are linked to an increased prevalence of hyperuricemia (HU) in a dose-response manner. This study highlights a significant association between calcium and HU risk.

Area of Science:

  • Biochemistry
  • Clinical Medicine
  • Epidemiology

Background:

  • Hyperuricemia (HU) is a metabolic condition associated with various health issues.
  • Serum calcium (Ca) levels are crucial for numerous physiological processes.
  • Understanding the relationship between serum Ca and HU is important for public health.

Purpose of the Study:

  • To investigate the association between serum calcium levels and the prevalence of hyperuricemia.
  • To determine if a dose-response relationship exists between serum Ca and HU.
  • To analyze this relationship in a large population-based cohort.

Main Methods:

  • Data from 6337 subjects at Xiangya Hospital Health Management Centre were analyzed.
  • Serum Ca was measured using the Arsenazo III method.
  • Logistic and spline regression models evaluated the association between serum Ca and HU prevalence.

Main Results:

  • The overall prevalence of HU was 17.5%.
  • A positive dose-response relationship was observed: higher serum Ca quintiles showed significantly increased odds of HU.
  • Adjusted odds ratios for HU increased progressively with higher serum Ca levels (P for trend <.001).

Conclusions:

  • Higher serum calcium levels are significantly associated with a higher prevalence of hyperuricemia.
  • A clear dose-response relationship exists between serum Ca and HU.
  • These findings suggest a potential link between calcium metabolism and uric acid levels.

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