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Effectiveness and safety of lactobacilli in children with functional constipation: Study protocol for a meta-analysis

Wenhao Yang1,2, Tao He3, Weijian Zhang1,2

  • 1Department of Pediatrics, West China Second University Hospital, Sichuan University, Guoxuexiang, Chengdu.

Medicine
|May 18, 2019
PubMed

Insights

This systematic review evaluates lactobacilli as a treatment for childhood constipation. The analysis of randomized controlled trials will clarify the effectiveness and safety of these probiotics for pediatric patients.

Area of Science:

  • Pediatric Gastroenterology
  • Microbiome Research
  • Evidence-Based Medicine

Background:

  • Childhood constipation is a prevalent condition with significant healthcare costs.
  • Standard treatments are ineffective for some children, persisting into adolescence.
  • Lactobacilli are explored as alternative therapies, but their efficacy and safety require investigation.

Purpose of the Study:

  • To systematically review and meta-analyze the effectiveness and safety of lactobacilli for treating constipation in children.
  • To provide evidence-based insights into the use of probiotics for pediatric constipation.

Main Methods:

  • Systematic review and meta-analysis adhering to PRISMA protocols.
  • Searched PubMed, Embase, and Cochrane Library up to December 20, 2018.
  • Included randomized controlled trials, assessing primary outcomes (defecation frequency, treatment success) and secondary outcomes (stool consistency, pain, laxative use, adverse events).

Main Results:

  • The meta-analysis will synthesize data from selected randomized controlled trials.
  • Results will quantify the impact of lactobacilli on defecation frequency and treatment success.
  • Safety data, including adverse events and abdominal pain, will be evaluated.

Conclusions:

  • The study will offer valuable information on the efficacy and safety of lactobacilli for pediatric constipation.
  • Findings will inform clinical practice and future research directions.
  • Results are intended for publication in a peer-reviewed journal.
Abstract

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