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Hypertensive disorders during pregnancy and elevated blood pressure in the offspring: A systematical review and
Huan Yu1, Yuan He1, Zhengxia Mao1
1Department of Neonatology.
Insights
Hypertensive disorders during pregnancy (HDP) can impact offspring blood pressure (BP). This systematic review analyzes HDP subtypes to clarify their specific associations with elevated BP in children.
Area of Science:
- Obstetrics and Gynecology
- Pediatrics
- Cardiovascular Health
Background:
- Hypertensive disorders during pregnancy (HDP), encompassing gestational hypertension, preeclampsia (PE), and chronic hypertension, affect about 10% of pregnancies globally.
- Previous research indicates a link between PE and elevated offspring blood pressure (BP).
- A comprehensive systematic review on the association between various HDP subtypes and offspring BP is currently lacking.
Purpose of the Study:
- To systematically review and meta-analyze existing literature to establish a clear consensus on the associations between different subtypes of hypertensive disorders during pregnancy (HDP) and blood pressure (BP) in offspring.
- To provide high-quality evidence on how specific HDP subtypes influence offspring BP.
Main Methods:
- Adherence to Cochrane Handbook and PRISMA guidelines for systematic reviews and meta-analyses.
- Inclusion of cohort, case-control, and cross-sectional studies examining HDP subtypes and offspring BP.
- Systematic literature search across major databases (PubMed, Embase, Cochrane Library, Web of Science) with rigorous data extraction and quality assessment.
Main Results:
- This systematic review and meta-analysis will synthesize data to quantify the effects of different HDP subtypes on offspring BP.
- The study aims to provide robust evidence regarding the specific impact of each HDP subtype on the blood pressure of offspring.
Conclusions:
- The systematic review will conclude on the specific associations between various hypertensive disorders during pregnancy (HDP) subtypes and the blood pressure of offspring.
- Findings will contribute to a better understanding of the long-term cardiovascular health implications for children born to mothers with HDP.
Background:
Hypertensive disorders during pregnancy (HDP), including gestational hypertension, preeclampsia (PE), and chronic hypertension, affect approximately 10% of pregnancies worldwide. PE was associated with elevated blood pressure (BP) in the offspring confirmed by previous literature. No previous systematic review has investigated the associations between the subtypes of HDP and BP in offspring. Therefore, from the published literature, the present systematic review and meta-analysis aims to reach to a clear consensus on this topic.
Methods:
The Cochrane Handbook for Systematic Reviews of Interventions was used to structure our methodological approach, and the Preferred Reporting Items for Systematic Reviews and Meta Analyses Protocols guidelines to this protocol. We will include cohort, case-control, and cross-sectional studies, in which HDP or its subtypes were reported and BP in the offspring was the outcome of interest. A systematic search of PubMed, Embase, the Cochrane library, and Web of Science will be conducted according to a specific search strategy. The titles and abstracts of all literature will be reviewed independently by 2 authors. A standardized data collection form will be used for data extraction. The overall pooled estimates will be calculated by meta-analysis in Revman 5.3 based on an inverse variance method. According to the heterogeneity by the I, a random-effect model or a fixed-effect model will be chosen to pool data. Risk of bias and quality of the studies will be assessed by a suitable bias classification tool.
Results:
This study will provide high-quality evidence of the effects in offspring BP, which were influenced by different subtypes of HDP.
Conclusion:
This systematic review will infer a conclusion on the associations between different subtypes of HDP and BP in offspring.
Ethics And Dissemination:
Due to the data come from the published study, the present systematic review and meta-analysis does not require ethics approval. Findings will be published in a peer-reviewed journal.
Registration:
Supporting data can be found at the International Prospective Register of Systematic Reviews (PROSPERO) website, with registration number CRD 42018110872.
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